Category: pyrazoles-derivatives

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 26621-44-3, name is 3-Nitro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., 26621-44-3

At room temperature, water (15 mL) was added to a mixture of 3-nitro-1H-pyrazole (48a) (1 g, 8.90 mmol) and NBS (1.73 g, 9.70 mmol), and the reaction was stirred overnight. After thin layer chromatography indicated the reaction was complete, the reaction solution was diluted with water, extracted with ethyl acetate, washed with saturated brine, dried over anhydrous sodium sulfate, concentrated under reduced pressure, and rotary evaporated to dryness, to afford compound (48b) (1.66 g, yield: 93%, white solid). MS (ESI, m/z): 192 [M+H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

A common compound: 120068-79-3, name is 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 120068-79-3

General procedure: A mixture of compound A (5 mmol) and corresponding benzaldehyde (5 mmol) in 10 mL ethanol was refluxed for 24 hours in a reaction flask wrapped up by silver paper. Upon the reactions completed (monitored by TLC), tawny solids were obtained through suction filtration. The precipitates were washed with ethanol (5 mLx3) and recrystallized from ethanol with 50-84% yields.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 120068-79-3, other downstream synthetic routes, hurry up and to see.

1120-82-7, name is (1H-Pyrazol-1-yl)methanol, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 1120-82-7

To a solution of lH-pyrazol-1-ylmethanol (4.33 mg, 44.1 mmol) in anhydrous dichloromethane (130 mL) was added dropwise a solution of phosphorus tribromide (4.2 mL, 44.1 mmol) in anhydrous dichloromethane (20 mL) at 00C. The mixture was stirred for 2.5 hours at room temperature. The mixture was evaporated, and the crude l-(bromomethyl)-lH-pyrazole was used in the next step without purification.

Statistics shows that 1120-82-7 is playing an increasingly important role. we look forward to future research findings about (1H-Pyrazol-1-yl)methanol.

330792-70-6, Adding a certain compound to certain chemical reactions, such as: 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 330792-70-6.

5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile (28 mg, 0.1 mmol)A mixture of 2-Bromomalonaldehyde (15 mg, 0.1 mmol) in EtOH (5 mL) was stirred at room temperature for 2 hours.The mixture was then filtered to give a crude yellow solid (20 mg, 62.9percent).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, other downstream synthetic routes, hurry up and to see.

402-61-9, Name is 5-Methyl-1H-pyrazole-3-carboxylic acid, 402-61-9, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

To a solution of 5-methyl-1H-pyrazole-3-carboxylic acid (45 g) in MeOH (450 mL) is added dropwise thionylchloride (58 mL). After addition the mixture is stirred for 16 h at room temperature. The mixture is concentrated in vacuo. The residue is dissolved in EtOAC, washed successively with saturated aqueous NaHCO3 and brine. After drying (MgSO4) the mixture is concentrated in vacuo to give the title compound. LC (Method 1): tR=0.64 min; Mass spectrum (ESI+): m/z=141 [M+H]+.

Statistics shows that 5-Methyl-1H-pyrazole-3-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 402-61-9.

A common heterocyclic compound, 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, molecular formula is C4H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1120-82-7.

General procedure: To a solution of N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-3-hydroxybenzamide (12) (0.250g, 0.838mmol) in anhydrous THF (5mL), the corresponding alcohol (0.838mmol) and PPh3 (0.330g, 1.25mmol) were added. The reaction mixture was cooled on ice bath and DIAD (0.25mL, 1.25mmol) was added. The reaction was stirred overnight at room temperature. The solvent was evaporated under reduced pressure and the crude product was purified by flash chromatography.

The synthetic route of (1H-Pyrazol-1-yl)methanol has been constantly updated, and we look forward to future research findings.

1192-21-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1192-21-8 as follows.

Sparge a solution of 2-(2-chloro-4-pyridyi)-5-2-cyclopropoxy)ethyl]-6,6- dimethyi-thieno[2,3-c]pyrrol-4-one (13.9 g, 121 mmol), i-methyi-5-aminopyrazole (ii g, 113 rnrnoi), and sodium tert-butoxide (6.5 g, 68 mrnol) in toluene (150 mL) with nitrogen for 15 minutes. Treat the resulting mixture with (R)- I -[(Sp)-2- (dicyciohexyiphosphino)ferrocenyiiethyldi-tert-hutylphosphine (200 mg, 0.36 mmol) andbis(tri-o-toiyiphosphine)paliadium(0) (250 mg, 0.35 mmoi), Heat the reaction mixture to reflux for one hour. Cool the reaction to room temperature and dilute with EtOAc (500 mL), Wash the organic solution with water (300 mL), Separate and concentrate the organic phase under reduced pressure, Dissolve the residue inDCM (150 mL) and treat the solution with SILIAMETS Thiol (40 g, I .28 mrnol/g, 40-63 micron) and stir the mixture for four hours, Filter to remove the solid and concentrate the filtrate under reduced pressure to give the title compound I LI g (86%). MS (ink): 424 (M+i).

According to the analysis of related databases, 1-Methyl-1H-pyrazol-5-amine, the application of this compound in the production field has become more and more popular.

3920-50-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3920-50-1 name is Pyrazole-3-carboxaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

3.9 mg of 1H-pyrazole-3-carboxaldehyde was added to a dimethylformamide (0.5 ml) solution of 15 mg of 4-(2-fluoro-phenoxy)-5-(6-methanesulfonyl-pyridin-3-yloxy)-benzene-1,2-diamine obtained in Example 200, and the reaction liquid was stirred at 90¡ãC for 30 minutes. The solvent was evaporated away under reduced pressure, and the resulting residue was purified through partitioning thin-layer chromatography (Kieselgel.(TM). 60F254, Art 5744 (by Merck), chloroform/methanol = 9/1) to obtain the entitled compound as a white solid. 1HNMR(CDCl3)delta: 3.20(3H,s), 6.94-6.99(1H,m), 7.01-7.15(4H,m), 7.25-7.65(2H,m), 7.31(1H,dd,J=8.9,2.7Hz), 7.66(1H,d,J=2.3Hz), 7.98(1H,d,J=8.9Hz), 8.40(1H,d,J=2.7Hz) ESI-MS(m/e):466[M+H]

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Pyrazole-3-carboxaldehyde, and friends who are interested can also refer to it.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16034-46-1 name is 1-Methyl-1H-pyrazole-5-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 16034-46-1

Oxalyl chloride (0.088 g, 0.693 mmol) was added to a slurry of 1 -methyl- 1 H- pyrazole-5-carboxylic acid (0.066 g, 0.523 mmol) in dichloromethane (2 ml). One drop dimethylformamide was added and the reaction left to stir at room temperature for 2 hours. The reaction was concentrated in vacuo and azeotroped with dichloromethane. The residue was dissolved in THF (2 ml) and to this was added diisopropylethylamine (0.0956 g, 0.693 mmol) and 4- pyrrolidinopyridine (0.005 g, 0.035 mmol). The solution was cooled in an ice/acetone bath and 3-(2,3,5-trichlorophenyl)pyridine-2,6-diamine (Preparation 6, 0.100 g, 0.347 mmol) added portion-wise over 1 minute. The reaction was warmed to room temperature and stirred for 18 hours. The reaction was diluted with dichloromethane and washed with a saturated aqueous solution of NH4CI (10 ml), followed by a saturated aqueous solution of NaHCO3 (10 ml) and then water (10 ml) before drying over MgSO4 and concentrating in vacuo to afford a brown gum. The residue was purified by trituration with pentane to afford the title compound as a yellow oil. 1HNMR (ck-DMSO): 4.09 (s, 3H), 5.60 (br s, 2H), 7.22 (d, 1 H), 7.33 (d, 1 H), 7.38 (d, 1 H), 7.42 (d, 1 H), 7.50 (d, 1 H), 7.84 (d, 1 H), 10.30 (br s, 1 H)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-pyrazole-5-carboxylic acid, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 26621-44-3, name is 3-Nitro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., 26621-44-3

To a mixture of 3-nitro-iH-pyrazole (30 g, 265.31 mmol, 1 eq) in DMF (300 mL) was added NaH (11.14 g, 278.58 mmol, 60% purity in mineral oil, 1.05 eq) in portions at o C. Then the reaction mixture was stirred at o C for 0.5 hour. 2-Bromopropane (39.16 g, 318.37 mmol, 1.2 eq) was added and the resulting mixture was warmed to 25 C for 12 hours. The reaction mixture was quenched with water (500 mL) and extracted with EtOAc (3 x 300 mL). The combined organic layers were washed with brine (100 mL), dried over anhydrous Na2S04, filtered and concentrated in vacuo. The residue was purified by chromatography (Si02, petroleum ether: ethyl acetate, 50:1 to 2:1) to give the title compound (29.2 g, 71 %) as a yellow oil. (0810) NMR (400 MHz, CDCI3) d 749 (d, 1 H), 6.90 (d, 1 H), 4-634-56 (m, 1 H) and 1.58 (d, 6 H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.