{"id":9994,"date":"2022-10-13T03:03:03","date_gmt":"2022-10-12T19:03:03","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=9994"},"modified":"2022-10-13T03:03:03","modified_gmt":"2022-10-12T19:03:03","slug":"heim-riether-alexanders-team-published-research-in-bioorganic-medicinal-chemistry-letters-in-2009-cas-29004-73-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=9994","title":{"rendered":"Heim-Riether, Alexander’s team published research in Bioorganic & Medicinal Chemistry Letters in 2009 | CAS: 29004-73-7"},"content":{"rendered":"

Reference of (3-methyl-1H-pyrazol-5-yl)methanol<\/a>On September 15, 2009 ,\u300aImproving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors\u300b was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Heim-Riether, Alexander; Taylor, Steven J.; Liang, Shuang; Gao, Donghong Amy; Xiong, Zhaoming; Michael August, E.; Collins, Brandon K.; Farmer, Bennett T.; Haverty, Kathleen; Hill-Drzewi, Melissa; Junker, Hans-Dieter; Mariana Margarit, S.; Moss, Neil; Neumann, Thomas; Proudfoot, John R.; Keenan, Lana Smith; Sekul, Renate; Zhang, Qiang; Li, Jun; Farrow, Neil A.. The article contains the following contents:<\/p>\n

Discovery and optimization of potency and selectivity of a non-Zn-chelating MMP-13 inhibitor with the aid of protein co-crystal structural information is reported. This inhibitor was observed to have a binding mode distinct from previously published MMP-13 inhibitors. Potency and selectivity were improved by extending the hit structure out from the active site into the S1′ pocket. In the experiment, the researchers used many compounds, for example, (3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7Reference of (3-methyl-1H-pyrazol-5-yl)methanol<\/a>)<\/p>\n

(3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Reference of (3-methyl-1H-pyrazol-5-yl)methanol<\/a><\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

(3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Reference of (3-methyl-1H-pyrazol-5-yl)methanol<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[622,131],"tags":[128],"class_list":["post-9994","post","type-post","status-publish","format-standard","hentry","category-29004-73-7","category-pyrazoles-derivatives","tag-100-200"],"yoast_head":"\nHeim-Riether, Alexander's team published research in Bioorganic & Medicinal Chemistry Letters in 2009 | CAS: 29004-73-7 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Reference of (3-methyl-1H-pyrazol-5-yl)methanolOn September 15, 2009 ,\u300aImproving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors\u300b was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Heim-Riether, Alexander; Taylor, Steven J.; Liang, Shuang; Gao, Donghong Amy; Xiong, Zhaoming; Michael August, E.; Collins, Brandon K.; Farmer, Bennett T.; Haverty, Kathleen; Hill-Drzewi, Melissa; Junker, Hans-Dieter; Mariana Margarit, S.; Moss, Neil; Neumann, Thomas; Proudfoot, John R.; Keenan, Lana Smith; Sekul, Renate; Zhang, Qiang; Li, Jun; Farrow, Neil A.. 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