{"id":9962,"date":"2022-10-12T07:02:02","date_gmt":"2022-10-11T23:02:02","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=9962"},"modified":"2022-10-12T07:02:02","modified_gmt":"2022-10-11T23:02:02","slug":"garcia-da-silva-artur-christians-team-published-research-in-chemico-biological-interactions-in-2020-07-01-13788-92-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=9962","title":{"rendered":"Garcia da Silva, Artur Christian’s team published research in Chemico-Biological Interactions in 2020-07-01 | 13788-92-6"},"content":{"rendered":"

Garcia da Silva, Artur Christian; Rodrigues, Bruna dos Santos; Andrade, Wanessa Machado; Marques dos Santos, Thais Rosa; de Carvalho, Flavio Silva; Sanz, German; Vaz, Boniek G.; Liao, Luciano M.; Menegatti, Ricardo; Valadares, Marize Campos published the artcile< Antiangiogenic and antitumoral activity of LQFM126 prototype against B16F10 melanoma cells>, Computed Properties of 13788-92-6<\/a>, the main research area is Nutlin analog antiangiogenic antitumoral agent melanoma cell; Antitumor drugs; Apoptosis; LQFM126; Melanoma; Molecular simplification; Nutlins.<\/p>\n

Inhibition of mouse double minute 2 homolog (MDM2)-p53 interaction and reactivation of p53 signaling have been explored as effective anticancer therapeutic strategy. The potent and specific antitumor activity shown by Nutlins, first class of MDM2-p53 inhibitors discovered, has made these compounds potential antitumor candidates. To this end, we synthesized Nutlin-1 and Nutlin-2 analogs through mol. simplification and selected the compound with the most efficient antitumoral activity. Cytotoxicity of Nutlin-2 analog LQFM126 on B16F10 melanoma cells induced intense cytoplasmic vacuolization, reduction of cell size, chromatin condensation, cytoplasmic degeneration and nuclear fragmentation. LQFM126 antiproliferative effects mediated cell cycle retention in G0\/G1 phase and increased the levels of cell cycle regulatory proteins p21 and p27. This Nutlin analog increased mitochondrial membrane potential, activated caspase-8, -9 and -3\/7 and reduced VEGF levels in B16F10 cells. Therefore, LQFM126 promoted alterations suggestive of apoptosis, G0\/G1 cell cycle arrest and suppression of angiogenesis through modulation of VEGF expression in B16F10 cells. Addnl., LQFM126 was classified as UN GHS category 4 (LD50 > 300-2000 mg\/kg), suggesting it has low acute systemic toxicity. LQFM126 can be a promising prototype for anticancer therapy.<\/p>\n

Chemico-Biological Interactions published new progress about Angiogenesis. 13788-92-6 belongs to class pyrazoles-derivatives, and the molecular formula is C9H7BrN2, Computed Properties of 13788-92-6<\/a>.<\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Chemico-Biological Interactions published new progress about Angiogenesis. 13788-92-6 belongs to class pyrazoles-derivatives, and the molecular formula is C9H7BrN2, Computed Properties of 13788-92-6<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[738,131],"tags":[716],"class_list":["post-9962","post","type-post","status-publish","format-standard","hentry","category-13788-92-6","category-pyrazoles-derivatives","tag-m-w200-250"],"yoast_head":"\nGarcia da Silva, Artur Christian's team published research in Chemico-Biological Interactions in 2020-07-01 | 13788-92-6 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Garcia da Silva, Artur Christian; Rodrigues, Bruna dos Santos; Andrade, Wanessa Machado; Marques dos Santos, Thais Rosa; de Carvalho, Flavio Silva; Sanz, German; Vaz, Boniek G.; Liao, Luciano M.; Menegatti, Ricardo; Valadares, Marize Campos published the artcile< Antiangiogenic and antitumoral activity of LQFM126 prototype against B16F10 melanoma cells>, Computed Properties of 13788-92-6, the main research area is Nutlin analog antiangiogenic antitumoral agent melanoma cell; Antitumor drugs; Apoptosis; LQFM126; Melanoma; Molecular simplification; Nutlins.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=9962\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Garcia da Silva, Artur Christian's team published research in Chemico-Biological Interactions in 2020-07-01 | 13788-92-6 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Garcia da Silva, Artur Christian; Rodrigues, Bruna dos Santos; Andrade, Wanessa Machado; Marques dos Santos, Thais Rosa; de Carvalho, Flavio Silva; Sanz, German; Vaz, Boniek G.; Liao, Luciano M.; Menegatti, Ricardo; Valadares, Marize Campos published the artcile< Antiangiogenic and antitumoral activity of LQFM126 prototype against B16F10 melanoma cells>, Computed Properties of 13788-92-6, the main research area is Nutlin analog antiangiogenic antitumoral agent melanoma cell; Antitumor drugs; Apoptosis; LQFM126; Melanoma; Molecular simplification; Nutlins.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=9962\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-11T23:02:02+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9962\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9962\",\"name\":\"Garcia da Silva, Artur Christian's team published research in Chemico-Biological Interactions in 2020-07-01 | 13788-92-6 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-10-11T23:02:02+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Garcia da Silva, Artur Christian; 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