{"id":9958,"date":"2022-10-12T07:01:16","date_gmt":"2022-10-11T23:01:16","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=9958"},"modified":"2022-10-12T07:01:16","modified_gmt":"2022-10-11T23:01:16","slug":"tan-yun-xuans-team-published-research-in-ccs-chemistry-in-2021-13788-92-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=9958","title":{"rendered":"Tan, Yun-Xuan’s team published research in CCS Chemistry in 2021 | 13788-92-6"},"content":{"rendered":"

Tan, Yun-Xuan; Liu, Xing-Yu; Zhang, Shuo-Qing; Xie, Pei-Pei; Wang, Xin; Feng, Kai-Rui; Yang, Shao-Qian; He, Zhi-Tao; Hong, Xin; Tian, Ping; Lin, Guo-Qiang published the artcile< An unconventional trans-exo-selective cyclization of alkyne-tethered cyclohexadienones initiated by rhodium(III)-catalyzed C-H activation via insertion relay>, Computed Properties of 13788-92-6<\/a>, the main research area is rhodium carbon hydrogen activation catalysis alkyne cyclohexadienone cyclization.<\/p>\n

Different from the established trans-endo-selective cyclization of alkyne-tethered electrophiles that involve an E\/Z isomerization process, herein, the authors present a novel strategy to allow trans-exo-selective arylative cyclization of 1,6-enynes. Through initiation of rhodium(III)-catalyzed C-H activation, a diverse range of N-heterocyclic directing groups, including pyridine, pyrazole, imidazo[1,2-a] pyridine, benzoxazole, benzothiazole, and purine, was feasible for the cascade transformation, exhibiting high efficiency (up to 92% yield), broad substrate scope, and excellent functional group compatibility. Moreover, the modification of natural products and pharmaceutical compounds was also demonstrated to showcase its synthetic utility. Based on d. functional theory (DFT) calculations, a key three-membered ring intermediate through the insertion relay, rather than the direct E\/Z isomerization of alkenyl rhodium species, controlled the stereochem. outcome for this trans-exo-selective cyclization. The subsequent ring-opening protonation of the more favored rotamer led to exclusive trans-exo-selectivity.<\/p>\n

CCS Chemistry published new progress about C-H bond activation. 13788-92-6 belongs to class pyrazoles-derivatives, and the molecular formula is C9H7BrN2, Computed Properties of 13788-92-6<\/a>.<\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

CCS Chemistry published new progress about C-H bond activation. 13788-92-6 belongs to class pyrazoles-derivatives, and the molecular formula is C9H7BrN2, Computed Properties of 13788-92-6<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[738,131],"tags":[716],"class_list":["post-9958","post","type-post","status-publish","format-standard","hentry","category-13788-92-6","category-pyrazoles-derivatives","tag-m-w200-250"],"yoast_head":"\nTan, Yun-Xuan's team published research in CCS Chemistry in 2021 | 13788-92-6 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Tan, Yun-Xuan; Liu, Xing-Yu; Zhang, Shuo-Qing; Xie, Pei-Pei; Wang, Xin; Feng, Kai-Rui; Yang, Shao-Qian; He, Zhi-Tao; Hong, Xin; Tian, Ping; Lin, Guo-Qiang published the artcile< An unconventional trans-exo-selective cyclization of alkyne-tethered cyclohexadienones initiated by rhodium(III)-catalyzed C-H activation via insertion relay>, Computed Properties of 13788-92-6, the main research area is rhodium carbon hydrogen activation catalysis alkyne cyclohexadienone cyclization.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=9958\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tan, Yun-Xuan's team published research in CCS Chemistry in 2021 | 13788-92-6 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Tan, Yun-Xuan; Liu, Xing-Yu; Zhang, Shuo-Qing; Xie, Pei-Pei; Wang, Xin; Feng, Kai-Rui; Yang, Shao-Qian; He, Zhi-Tao; Hong, Xin; Tian, Ping; Lin, Guo-Qiang published the artcile< An unconventional trans-exo-selective cyclization of alkyne-tethered cyclohexadienones initiated by rhodium(III)-catalyzed C-H activation via insertion relay>, Computed Properties of 13788-92-6, the main research area is rhodium carbon hydrogen activation catalysis alkyne cyclohexadienone cyclization.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=9958\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-11T23:01:16+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9958\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9958\",\"name\":\"Tan, Yun-Xuan's team published research in CCS Chemistry in 2021 | 13788-92-6 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-10-11T23:01:16+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Tan, Yun-Xuan; Liu, Xing-Yu; Zhang, Shuo-Qing; Xie, Pei-Pei; Wang, Xin; Feng, Kai-Rui; Yang, Shao-Qian; He, Zhi-Tao; Hong, Xin; Tian, Ping; Lin, Guo-Qiang published the artcile< An unconventional trans-exo-selective cyclization of alkyne-tethered cyclohexadienones initiated by rhodium(III)-catalyzed C-H activation via insertion relay>, Computed Properties of 13788-92-6, the main research area is rhodium carbon hydrogen activation catalysis alkyne cyclohexadienone cyclization.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9958#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=9958\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9958#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Tan, Yun-Xuan’s team published research in CCS Chemistry in 2021 | 13788-92-6\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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