{"id":994,"date":"2020-11-11T10:34:13","date_gmt":"2020-11-11T02:34:13","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=994"},"modified":"2020-11-11T10:34:13","modified_gmt":"2020-11-11T02:34:13","slug":"the-origin-of-a-common-compound-about-18048-64-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=994","title":{"rendered":"The origin of a common compound about 18048-64-1"},"content":{"rendered":"

A common compound: 18048-64-1, name is 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 18048-64-1<\/a><\/p>\n

4- (7-amino-6-hydroxy-2,3-dihydro-1H – inden-5-yl) benzoic acid hydrobromide(0.5g, 1.43mmol) was dissolved in 15ml of concentrated hydrochloric acid, cooled to 0 , theretowas slowly added dropwise of NaNO2(0.11 g of, 1.51 mmol) aqueous solution (10ml), the reaction incubated0.5h, TLC detection starting material the reaction was complete.Thereto was added 1- (3,4-dimethylphenyl) -3-methyl-1H – pyrazol-5 (4 hydrogen) -one (0.29g, 1.43mmol), the reaction 15min,controlling the reaction temperature is 0 deg.] C, with saturated sodium bicarbonate to adjust the pH value of about 9, was added 10mlof absolute ethanol, naturally to room temperature after the reaction was continued for 24h, TLC detection starting material the reaction was complete,filtered and the resulting cake was washed with 40ml of hydrochloric acid solution (concentration of 2mol \/ L) washed several times with methanolpulping, beating dichloromethane, filtration give (Z) -4- (7- (2- (1- (3,4-dimethylphenyl) -3-methyl-5-oxo substituting 1,5-dihydro – pyrazol-4-ylidene) hydrazino-yl) -6-hydroxy-2,3-dihydro -1H-indan-5-yl) benzoic acid (0.33mg, yield 44 %).<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 18048-64-1, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 18048-64-1, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[158,131],"tags":[127],"class_list":["post-994","post","type-post","status-publish","format-standard","hentry","category-18048-64-1","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nThe origin of a common compound about 18048-64-1<\/title>\n<meta name=\"description\" content=\"A common compound: 18048-64-1, name is 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 18048-64-1\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=994\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The origin of a common compound about 18048-64-1\" \/>\n<meta property=\"og:description\" content=\"A common compound: 18048-64-1, name is 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. 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