{"id":9922,"date":"2022-09-21T02:24:10","date_gmt":"2022-09-20T18:24:10","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=9922"},"modified":"2022-09-21T02:24:10","modified_gmt":"2022-09-20T18:24:10","slug":"lefranc-julien-team-published-research-on-journal-of-medicinal-chemistry-in-2020-269410-08-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=9922","title":{"rendered":"Lefranc, Julien team published research on Journal of Medicinal Chemistry in 2020 | 269410-08-4"},"content":{"rendered":"

Pyrazoles are synthesized by the reaction of \u03b1,\u03b2-unsaturated aldehydes with hydrazine and subsequent dehydrogenation. 269410-08-4, formula is C9H15BN2O2, Name is 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. Substituted pyrazoles are prepared by condensation of 1,3-diketones with hydrazine (Knorr-type reactions). For example, acetylacetone and hydrazine gives 3,5-dimethylpyrazole. Recommanded Product: 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole<\/a>.<\/p>\n

Lefranc, Julien;Schulze, Volker Klaus;Hillig, Roman Christian;Briem, Hans;Prinz, Florian;Mengel, Anne;Heinrich, Tobias;Balint, Jozsef;Rengachari, Srinivasan;Irlbacher, Horst;Stoeckigt, Detlef;Boemer, Ulf;Bader, Benjamin;Gradl, Stefan Nikolaus;Nising, Carl Friedrich;von Nussbaum, Franz;Mumberg, Dominik;Panne, Daniel;Wengner, Antje Margret research published \u300a Discovery of BAY-985, a Highly Selective TBK1\/IKK\u03b5 Inhibitor\u300b, the research content is summarized as follows. The serine\/threonine kinase TBK1 (TANK-binding kinase 1) and its homolog IKK\u03b5 are noncanonical members of the inhibitor of the nuclear factor \u03baB (I\u03baB) kinase family. These kinases play important roles in multiple cellular pathways and, in particular, in inflammation. Herein, we describe our investigations on a family of benzimidazoles and the identification of the potent and highly selective TBK1\/IKK\u03b5 inhibitor BAY-985. BAY-985 inhibits the cellular phosphorylation of interferon regulatory factor 3 and displays antiproliferative efficacy in the melanoma cell line SK-MEL-2 but showed only weak antitumor activity in the SK-MEL-2 human melanoma xenograft model.<\/p>\n

269410-08-4, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, also known as 4-Pyrazoleboronic acid pinacol ester , is a useful research compound. Its molecular formula is C9H15BN2O2 and its molecular weight is 194.04 g\/mol. The purity is usually 95%.<\/p>\n

4-Pyrazoleboronic acid pinacol ester is a useful reagent for Suzuki-Miyaura cross-couplings as well as Ruthenium-catalyzed asymmetric hydrogenation. 4-Pyrazoleboronic acid pinacol ester is also a useful reagent for preparing VEGF, Aurora, RHO (ROCK), Janus Kinase 2, c-MET, ALK, S-nitrsoflutathione reductase, CDC7, Acetyl-CoA carboxylase inhibitors.<\/p>\n

4-Pyrazoleboronic acid pinacol ester is used in the preparation of Rho kinase (ROCK) inhibitors as wella s other biologically active compounds.<\/p>\n

4-Pyrazoleboronic acid pinacol ester is an organic compound that is the product of a bifunctional coupling reaction between 4-pyrazolecarboxylic acid and pinacol. It has been shown to inhibit protein S6 kinase, which is involved in the regulation of cell growth and proliferation. This compound has also been shown to be effective against cancer cells, including those that are resistant to conventional chemotherapeutic drugs. 4-Pyrazoleboronic acid pinacol ester may also be used as a precursor for other compounds with pharmaceutical activity., Recommanded Product: 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole<\/a><\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

269410-08-4, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, also known as 4-Pyrazoleboronic acid pinacol ester , is a useful research compound. Its molecular formula is C9H15BN2O2 and its molecular weight is 194.04 g\/mol. The purity is usually 95%.<\/p>\n

4-Pyrazoleboronic acid pinacol ester is a useful reagent for Suzuki-Miyaura cross-couplings as well as Ruthenium-catalyzed asymmetric hydrogenation. 4-Pyrazoleboronic acid pinacol ester is also a useful reagent for preparing VEGF, Aurora, RHO (ROCK), Janus Kinase 2, c-MET, ALK, S-nitrsoflutathione reductase, CDC7, Acetyl-CoA carboxylase inhibitors.<\/p>\n

4-Pyrazoleboronic acid pinacol ester is used in the preparation of Rho kinase (ROCK) inhibitors as wella s other biologically active compounds.<\/p>\n

4-Pyrazoleboronic acid pinacol ester is an organic compound that is the product of a bifunctional coupling reaction between 4-pyrazolecarboxylic acid and pinacol. It has been shown to inhibit protein S6 kinase, which is involved in the regulation of cell growth and proliferation. This compound has also been shown to be effective against cancer cells, including those that are resistant to conventional chemotherapeutic drugs. 4-Pyrazoleboronic acid pinacol ester may also be used as a precursor for other compounds with pharmaceutical activity., Recommanded Product: 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[734,131],"tags":[717],"class_list":["post-9922","post","type-post","status-publish","format-standard","hentry","category-269410-08-4","category-pyrazoles-derivatives","tag-m-w150-200"],"yoast_head":"\nLefranc, Julien team published research on Journal of Medicinal Chemistry in 2020 | 269410-08-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Pyrazoles are synthesized by the reaction of \u03b1,\u03b2-unsaturated aldehydes with hydrazine and subsequent dehydrogenation. 269410-08-4, formula is C9H15BN2O2, Name is 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. Substituted pyrazoles are prepared by condensation of 1,3-diketones with hydrazine (Knorr-type reactions). For example, acetylacetone and hydrazine gives 3,5-dimethylpyrazole. 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