{"id":984,"date":"2020-11-10T10:54:45","date_gmt":"2020-11-10T02:54:45","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=984"},"modified":"2020-11-10T10:54:45","modified_gmt":"2020-11-10T02:54:45","slug":"new-downstream-synthetic-route-of-5952-92-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=984","title":{"rendered":"New downstream synthetic route of 5952-92-1"},"content":{"rendered":"

A common heterocyclic compound, 5952-92-1, name is 1-Methyl-1H-pyrazole-4-carboxylic acid, molecular formula is C5H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 5952-92-1<\/a>.<\/p>\n

A solution of 8-(4-amino-benzyl)-3-cyclopropylmethyl-1-(2-fluoro-benzyl)-3, 7- dihydro-purine-2,6-dione (50 mg, 0.12 mmol) [IN N, N DIMETHYLFORMAMIDE] at [25 oC] was treated with a solution of 1-methyl-1H-pyrazole-4-carboxylic acid (15 mg, 0.12 mmol), [O-BENZOTRIAZOL-L-YL-N, N. NN-TETRAMETHYLURONIUM] hexafluorophosphate (49.7 mg, 0. [L 3 MMOL), AND N, N-DIISOPROPYLETHYLAMINE (62, UL,] 0.36 mmol). The resulting solution was stirred at [25 oC] for 18 h. At this time, the reaction was concentrated in vacuo. The residue was dissolved in chloroform and then was washed with a IN aqueous hydrochloric acid solution [(1 X 10] mL) and a saturated aqueous sodium chloride solution [(1 X 10] mL). The organics were dried over magnesium sulfate, filtered, and concentrated in vacuo. Flash chromatography (Merck Silica gel 60,230- 400 mesh, 5: 95 methanol\/dichloromethane) afforded 1-methyl-1H-pyrazole-4- carboxylic acid {4-[3-cyclopropylmethyl-1-(2-fluoro-benzyl)-2, 6-dioxo-2,3, 6,7- tetrahydro-1H-purin-8-ylmethyl]-phenyl}-amide (13.5 mg, 21.5percent) as a tan solid<\/p>\n

The synthetic route of 1-Methyl-1H-pyrazole-4-carboxylic acid has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 1-Methyl-1H-pyrazole-4-carboxylic acid has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[196,131],"tags":[126],"class_list":["post-984","post","type-post","status-publish","format-standard","hentry","category-5952-92-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nNew downstream synthetic route of 5952-92-1<\/title>\n<meta name=\"description\" content=\"A common heterocyclic compound, 5952-92-1, name is 1-Methyl-1H-pyrazole-4-carboxylic acid, molecular formula is C5H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 5952-92-1.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=984\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New downstream synthetic route of 5952-92-1\" \/>\n<meta property=\"og:description\" content=\"A common heterocyclic compound, 5952-92-1, name is 1-Methyl-1H-pyrazole-4-carboxylic acid, molecular formula is C5H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 5952-92-1.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=984\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2020-11-10T02:54:45+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=984\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=984\",\"name\":\"New downstream synthetic route of 5952-92-1\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2020-11-10T02:54:45+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"A common heterocyclic compound, 5952-92-1, name is 1-Methyl-1H-pyrazole-4-carboxylic acid, molecular formula is C5H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 5952-92-1.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=984#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=984\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=984#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"New downstream synthetic route of 5952-92-1\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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