{"id":9831,"date":"2022-09-20T02:31:08","date_gmt":"2022-09-19T18:31:08","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=9831"},"modified":"2022-09-20T02:31:08","modified_gmt":"2022-09-19T18:31:08","slug":"gan-linling-team-published-research-on-journal-of-medicinal-chemistry-in-2021-761446-44-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=9831","title":{"rendered":"Gan, Linling team published research on Journal of Medicinal Chemistry in 2021 | 761446-44-0"},"content":{"rendered":"

Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns. 761446-44-0, formula is C10H17BN2O2, Name is 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. 1-Methyl-5-(trifluoromethyl)pyrazole underwent deprotonation and subsequent carboxylation mainly or exclusively at either the 4-position of the heterocycle or at the nitrogen-attached methyl group. Related Products of 761446-44-0<\/a>.<\/p>\n

Gan, Linling;Gan, Zongjie;Dan, Yanrong;Li, Yaowei;Zhang, Peiming;Chen, Shanwen;Ye, Zaijun;Pan, Tao;Wan, Chunmei;Hu, Xuelian;Yu, Yu research published \u300a Tetrazanbigen Derivatives as Peroxisome Proliferator-Activated Receptor Gamma (PPAR\u03b3) Partial Agonists: Design, Synthesis, Structure-Activity Relationship, and Anticancer Activities\u300b, the research content is summarized as follows. Tetrazanbigen (TNBG) is a novel sterol isoquinoline derivative with poor water solubility and moderate inhibitory effects on human cancer cell lines via lipoapoptosis induction. Herein, we developed a series of novel TNBG analogs with improved water solubility and antiproliferative activities. The CCK-8 assay enabled us to identify a novel compound, 14g, which strongly inhibited HepG2 and A549 cell growth with IC50<\/sub> values of 0.54 and 0.47\u03bcM, resp. The anticancer effects might be explained by the partial activation and upregulation of PPAR\u03b3 expression, as indicated by the transactivation assay and western blotting evaluation. Furthermore, the in vitro antiproliferative activity was verified in an in vivo xenograft model in which 14g strongly reduced tumor growth at a dose of 10 mg\/kg. In line with these pos. observations, 14g exhibited an excellent water solubility of 31.4 mg\/mL, which was more than 1000-fold higher than that of TNBG (4\u03bcg\/mL). Together, these results suggest that 14g is a promising anticancer therapeutic that deserves further investigation.<\/p>\n

761446-44-0, 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is a useful research compound. Its molecular formula is C10H17BN2O2 and its molecular weight is 208.07 g\/mol. The purity is usually 95%., Related Products of 761446-44-0<\/a><\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

761446-44-0, 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is a useful research compound. Its molecular formula is C10H17BN2O2 and its molecular weight is 208.07 g\/mol. The purity is usually 95%., Related Products of 761446-44-0<\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[733,131],"tags":[716],"class_list":["post-9831","post","type-post","status-publish","format-standard","hentry","category-761446-44-0","category-pyrazoles-derivatives","tag-m-w200-250"],"yoast_head":"\nGan, Linling team published research on Journal of Medicinal Chemistry in 2021 | 761446-44-0 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns. 761446-44-0, formula is C10H17BN2O2, Name is 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. 1-Methyl-5-(trifluoromethyl)pyrazole underwent deprotonation and subsequent carboxylation mainly or exclusively at either the 4-position of the heterocycle or at the nitrogen-attached methyl group. 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