{"id":9795,"date":"2022-09-19T02:07:37","date_gmt":"2022-09-18T18:07:37","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=9795"},"modified":"2022-09-19T02:07:37","modified_gmt":"2022-09-18T18:07:37","slug":"da-costa-laurene-team-published-research-on-european-journal-of-medicinal-chemistry-in-2017-269410-08-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=9795","title":{"rendered":"Da Costa, Laurene team published research on European Journal of Medicinal Chemistry in 2017 | 269410-08-4"},"content":{"rendered":"

Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. 269410-08-4, formula is C9H15BN2O2, Name is 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 \u00b0C).Pyrazole used as a ligand to prepare organometallic compounds. Formula: C9H15BN2O2<\/a>.<\/p>\n

Da Costa, Laurene;Scheers, Els;Coluccia, Antonio;Rosetti, Alessia;Roche, Manon;Neyts, Johan;Terme, Thierry;Cirilli, Roberto;Mirabelli, Carmen;Silvestri, Romano;Vanelle, Patrice research published \u300a Heterocyclic pharmacochemistry of new rhinovirus antiviral agents: A combined computational and experimental study\u300b, the research content is summarized as follows. Rhinovirus (RV), member of the Enterovirus genus, is known to be involved in more than half of the common colds. Through advances in mol. biol., rhinoviruses have also been associated with exacerbations of chronic pulmonary diseases (e.g., asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis). In the current investigation, the authors develop a novel series of 4,5-dimethoxybenzyl derivatives that potently inhibits rhinovirus replication. Compound (S)-7f ((S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2-(4,5-dimethoxy-2-nitrophenyl)ethanol) blocks RV-B14 replication with an EC50<\/sub> value of 0.25 \u03bcM and shows a low toxicity in HeLa cells (CC50<\/sub> > 271 \u03bcM). Enantioseparation followed by an absolute configuration determination by a Mosher’s method revealed the interest of enantiopure compounds Mol. docking studies permitted the identification of key biol. interactions within the drug-binding pocket and an in silico drug-like study revealed a good potential for the development of these derivatives<\/p>\n

Formula: C9H15BN2O2<\/a>, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, also known as 4-Pyrazoleboronic acid pinacol ester , is a useful research compound. Its molecular formula is C9H15BN2O2 and its molecular weight is 194.04 g\/mol. The purity is usually 95%.<\/p>\n

4-Pyrazoleboronic acid pinacol ester is a useful reagent for Suzuki-Miyaura cross-couplings as well as Ruthenium-catalyzed asymmetric hydrogenation. 4-Pyrazoleboronic acid pinacol ester is also a useful reagent for preparing VEGF, Aurora, RHO (ROCK), Janus Kinase 2, c-MET, ALK, S-nitrsoflutathione reductase, CDC7, Acetyl-CoA carboxylase inhibitors.<\/p>\n

4-Pyrazoleboronic acid pinacol ester is used in the preparation of Rho kinase (ROCK) inhibitors as wella s other biologically active compounds.<\/p>\n

4-Pyrazoleboronic acid pinacol ester is an organic compound that is the product of a bifunctional coupling reaction between 4-pyrazolecarboxylic acid and pinacol. It has been shown to inhibit protein S6 kinase, which is involved in the regulation of cell growth and proliferation. This compound has also been shown to be effective against cancer cells, including those that are resistant to conventional chemotherapeutic drugs. 4-Pyrazoleboronic acid pinacol ester may also be used as a precursor for other compounds with pharmaceutical activity., 269410-08-4.<\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Formula: C9H15BN2O2<\/a>, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, also known as 4-Pyrazoleboronic acid pinacol ester , is a useful research compound. Its molecular formula is C9H15BN2O2 and its molecular weight is 194.04 g\/mol. The purity is usually 95%.<\/p>\n

4-Pyrazoleboronic acid pinacol ester is a useful reagent for Suzuki-Miyaura cross-couplings as well as Ruthenium-catalyzed asymmetric hydrogenation. 4-Pyrazoleboronic acid pinacol ester is also a useful reagent for preparing VEGF, Aurora, RHO (ROCK), Janus Kinase 2, c-MET, ALK, S-nitrsoflutathione reductase, CDC7, Acetyl-CoA carboxylase inhibitors.<\/p>\n

4-Pyrazoleboronic acid pinacol ester is used in the preparation of Rho kinase (ROCK) inhibitors as wella s other biologically active compounds.<\/p>\n

4-Pyrazoleboronic acid pinacol ester is an organic compound that is the product of a bifunctional coupling reaction between 4-pyrazolecarboxylic acid and pinacol. It has been shown to inhibit protein S6 kinase, which is involved in the regulation of cell growth and proliferation. This compound has also been shown to be effective against cancer cells, including those that are resistant to conventional chemotherapeutic drugs. 4-Pyrazoleboronic acid pinacol ester may also be used as a precursor for other compounds with pharmaceutical activity., 269410-08-4.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[734,131],"tags":[717],"class_list":["post-9795","post","type-post","status-publish","format-standard","hentry","category-269410-08-4","category-pyrazoles-derivatives","tag-m-w150-200"],"yoast_head":"\nDa Costa, Laurene team published research on European Journal of Medicinal Chemistry in 2017 | 269410-08-4 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. 269410-08-4, formula is C9H15BN2O2, Name is 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. 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