{"id":9788,"date":"2022-09-19T02:07:37","date_gmt":"2022-09-18T18:07:37","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=9788"},"modified":"2022-09-19T02:07:37","modified_gmt":"2022-09-18T18:07:37","slug":"cho-jong-hyun-team-published-research-on-tetrahedron-letters-in-2015-37622-90-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=9788","title":{"rendered":"Cho, Jong hyun team published research on Tetrahedron Letters in 2015 | 37622-90-5"},"content":{"rendered":"

Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. 37622-90-5, formula is C6H8N2O2, Name is Ethyl 4-pyrazolecarboxylate. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 \u00b0C).Pyrazole used as a ligand to prepare organometallic compounds. Application In Synthesis of 37622-90-5<\/a>.<\/p>\n

Cho, Jong hyun;Coats, Steven J.;Schinazi, Raymond F. research published \u300a Synthesis of carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases\u300b, the research content is summarized as follows. New carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases were synthesized and evaluated as potential anti-HIV and anti-HCV agents. Among the synthesized carbocyclic nucleoside analogs, the pyrazole amide 15<\/strong>f exhibited modest selective anti-HIV-1 activity (EC50<\/sub> = 24 \u03bcM).<\/p>\n

Application In Synthesis of 37622-90-5<\/a>, Ethyl 4-pyrazolecarboxylate, also known as Ethyl pyrazole-4-carboxylate, is a useful research compound. Its molecular formula is C6H8N2O2 and its molecular weight is 140.14 g\/mol. The purity is usually 95%.<\/p>\n

Ethyl pyrazole-4-carboxylate is a low yield, transition metal salt that is used in the synthesis of pyrazoles. It can be synthesized by the reaction of sodium ethoxide with ethyl chloroformate and a Grignard reagent. Sodium ethoxide is added to a suspension of sodium chloride and dried ethyl chloroformate, followed by addition of magnesium turnings. The mixture is refluxed for one hour, cooled, and filtered to give crystals. Ethyl pyrazole-4-carboxylate is used in the preparation of ethyl esters from aliphatic alcohols by reacting with boron trichloride or phosphorus pentachloride. It participates in certain chemical reactions as a byproduct and can damage equipment during chemical reactions. The yield of this compound can be increased by using an excess amount of Grignard reagent or adding hexamethylenetetramine to the reaction mixture, 37622-90-5.<\/p>\n

Referemce:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Application In Synthesis of 37622-90-5<\/a>, Ethyl 4-pyrazolecarboxylate, also known as Ethyl pyrazole-4-carboxylate, is a useful research compound. Its molecular formula is C6H8N2O2 and its molecular weight is 140.14 g\/mol. The purity is usually 95%.<\/p>\n

Ethyl pyrazole-4-carboxylate is a low yield, transition metal salt that is used in the synthesis of pyrazoles. It can be synthesized by the reaction of sodium ethoxide with ethyl chloroformate and a Grignard reagent. Sodium ethoxide is added to a suspension of sodium chloride and dried ethyl chloroformate, followed by addition of magnesium turnings. The mixture is refluxed for one hour, cooled, and filtered to give crystals. Ethyl pyrazole-4-carboxylate is used in the preparation of ethyl esters from aliphatic alcohols by reacting with boron trichloride or phosphorus pentachloride. It participates in certain chemical reactions as a byproduct and can damage equipment during chemical reactions. The yield of this compound can be increased by using an excess amount of Grignard reagent or adding hexamethylenetetramine to the reaction mixture, 37622-90-5.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[218,131],"tags":[732],"class_list":["post-9788","post","type-post","status-publish","format-standard","hentry","category-37622-90-5","category-pyrazoles-derivatives","tag-m-w100-150"],"yoast_head":"\nCho, Jong hyun team published research on Tetrahedron Letters in 2015 | 37622-90-5 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. 37622-90-5, formula is C6H8N2O2, Name is Ethyl 4-pyrazolecarboxylate. 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