{"id":9743,"date":"2022-04-20T04:14:06","date_gmt":"2022-04-19T20:14:06","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=9743"},"modified":"2022-04-20T04:14:06","modified_gmt":"2022-04-19T20:14:06","slug":"interesting-scientific-research-on-1300746-79-5-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=9743","title":{"rendered":"Interesting scientific research on 1300746-79-5"},"content":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/1300746-79-5.html\">Category: pyrazoles-derivatives<\/a>. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors. Author is Ouvry, Gilles; Clary, Laurence; Tomas, Loic; Aurelly, Michele; Bonnary, Laetitia; Borde, Emilie; Bouix-Peter, Claire; Chantalat, Laurent; Defoin-Platel, Claire; Deret, Sophie; Forissier, Mathieu; Harris, Craig S.; Isabet, Tatiana; Lamy, Laurent; Luzy, Anne-Pascale; Pascau, Jonathan; Soulet, Catherine; Taddei, Alessandro; Taquet, Nathalie; Thoreau, Etienne; Varvier, Emeric; Vial, Emmanuel; Hennequin, Laurent F..<\/p>\n<p>Minor structural modifications (sometimes single atom changes) can have a dramatic impact on the properties of compounds This is illustrated here on structures related to known mTOR inhibitor Sapanisertib. Subtle changes in the hinge binder lead to strikingly different overall profiles with changes in phys. properties, metabolism, and kinase selectivity.<\/p>\n<p>This compound((1,10-Phenanthroline)(trifluoromethyl)copper(I))<a href=\"https:\/\/www.ambeed.com\/products\/1300746-79-5.html\">Category: pyrazoles-derivatives<\/a> was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/A><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This compound((1,10-Phenanthroline)(trifluoromethyl)copper(I))<a href=\"https:\/\/www.ambeed.com\/products\/1300746-79-5.html\">Category: pyrazoles-derivatives<\/a> was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[726,131],"tags":[167],"class_list":["post-9743","post","type-post","status-publish","format-standard","hentry","category-1300746-79-5","category-pyrazoles-derivatives","tag-m-w300-400"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Interesting scientific research on 1300746-79-5 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Category: pyrazoles-derivatives. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors. Author is Ouvry, Gilles; Clary, Laurence; Tomas, Loic; Aurelly, Michele; Bonnary, Laetitia; Borde, Emilie; Bouix-Peter, Claire; Chantalat, Laurent; Defoin-Platel, Claire; Deret, Sophie; Forissier, Mathieu; Harris, Craig S.; Isabet, Tatiana; Lamy, Laurent; Luzy, Anne-Pascale; Pascau, Jonathan; Soulet, Catherine; Taddei, Alessandro; Taquet, Nathalie; Thoreau, Etienne; Varvier, Emeric; Vial, Emmanuel; Hennequin, Laurent F..\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=9743\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Interesting scientific research on 1300746-79-5 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Category: pyrazoles-derivatives. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors. Author is Ouvry, Gilles; Clary, Laurence; Tomas, Loic; Aurelly, Michele; Bonnary, Laetitia; Borde, Emilie; Bouix-Peter, Claire; Chantalat, Laurent; Defoin-Platel, Claire; Deret, Sophie; Forissier, Mathieu; Harris, Craig S.; Isabet, Tatiana; Lamy, Laurent; Luzy, Anne-Pascale; Pascau, Jonathan; Soulet, Catherine; Taddei, Alessandro; Taquet, Nathalie; Thoreau, Etienne; Varvier, Emeric; Vial, Emmanuel; Hennequin, Laurent F..\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=9743\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-04-19T20:14:06+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9743\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9743\",\"name\":\"Interesting scientific research on 1300746-79-5 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-04-19T20:14:06+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Category: pyrazoles-derivatives. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors. Author is Ouvry, Gilles; Clary, Laurence; Tomas, Loic; Aurelly, Michele; Bonnary, Laetitia; Borde, Emilie; Bouix-Peter, Claire; Chantalat, Laurent; Defoin-Platel, Claire; Deret, Sophie; Forissier, Mathieu; Harris, Craig S.; Isabet, Tatiana; Lamy, Laurent; Luzy, Anne-Pascale; Pascau, Jonathan; Soulet, Catherine; Taddei, Alessandro; Taquet, Nathalie; Thoreau, Etienne; Varvier, Emeric; Vial, Emmanuel; Hennequin, Laurent F..\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9743#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=9743\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9743#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Interesting scientific research on 1300746-79-5\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"http:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/cn.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/cn.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Interesting scientific research on 1300746-79-5 | pyrazoles-derivatives","description":"Category: pyrazoles-derivatives. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors. 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