{"id":9741,"date":"2022-04-20T04:14:06","date_gmt":"2022-04-19T20:14:06","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=9741"},"modified":"2022-04-20T04:14:06","modified_gmt":"2022-04-19T20:14:06","slug":"little-discovery-in-the-laboratory-a-new-route-for-25956-17-6-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=9741","title":{"rendered":"Little discovery in the laboratory: a new route for 25956-17-6"},"content":{"rendered":"<p>So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Doguc, Duygu Kumbul; Deniz, Firdevs; Ilhan, Ilter; Ergonul, Esin; Gultekin, Fatih researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).<a href=\"https:\/\/www.ambeed.com\/products\/25956-17-6.html\">Synthetic Route of C18H14N2Na2O8S2<\/a>.They published the article \u300aPrenatal exposure to artificial food colorings alters NMDA receptor subunit concentrations in rat hippocampus\u300b about this compound( cas:25956-17-6 )  in Nutritional Neuroscience. Keywords: hippocampus NMDA receptor erythrosine tartrazine amaranth; Artificial food colors; NMDARs; NR2A; NR2B; forced swim test; open field test; spatial learning and memory; \u03b17 nAChR. We&#8217;ll tell you more about this compound (cas:25956-17-6).<\/p>\n<p>Exposure to artificial food color additives (AFCAs) has been implicated in the etiol. of certain childhood hyperactivity and learning disabilities. N-methyl-D-aspartate receptors and alpha-7 nicotinic acetylcholine receptor (\u03b17 nAChR) are involved in learning and memory. We administered a mixture of AFCAs (erythrosine, ponceau 4R, allura red AC, sunset yellow FCF, tartrazine, amaranth, brilliant blue, azorubine, and indigotine) to female rats during gestation to investigate the effects of prenatal exposure to AFCAs on neurobehavior, spatial learning, and memory in their offspring. We also investigated whether AFCAs modulate NR2A, NR2B, and \u03b17 nAChR protein levels in their offsprings\u2032 hippocampi. Although spatial learning and memory were not altered, the offspring of rats exposed to AFCAs exhibited decreased motivation and increased despair-related behavior. NR2A and NR2B protein levels were significantly reduced in female offspring in the exptl. group (p < 0.05), whereas \u03b17 nAChR level was not significantly altered. Our results suggest that prenatal exposure to AFCAs may lead to sex-dependent alterations in glutamatergic signaling which may continue into adolescence.\n\nThis compound(Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate)<a href=\"https:\/\/www.ambeed.com\/products\/25956-17-6.html\">Synthetic Route of C18H14N2Na2O8S2<\/a> was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/A><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This compound(Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate)<a href=\"https:\/\/www.ambeed.com\/products\/25956-17-6.html\">Synthetic Route of C18H14N2Na2O8S2<\/a> was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[727,131],"tags":[500],"class_list":["post-9741","post","type-post","status-publish","format-standard","hentry","category-25956-17-6","category-pyrazoles-derivatives","tag-m-w400-500"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Little discovery in the laboratory: a new route for 25956-17-6 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Doguc, Duygu Kumbul; Deniz, Firdevs; Ilhan, Ilter; Ergonul, Esin; Gultekin, Fatih researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).Synthetic Route of C18H14N2Na2O8S2.They published the article \u300aPrenatal exposure to artificial food colorings alters NMDA receptor subunit concentrations in rat hippocampus\u300b about this compound( cas:25956-17-6 ) in Nutritional Neuroscience. Keywords: hippocampus NMDA receptor erythrosine tartrazine amaranth; Artificial food colors; NMDARs; NR2A; NR2B; forced swim test; open field test; spatial learning and memory; \u03b17 nAChR. We&#039;ll tell you more about this compound (cas:25956-17-6).\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=9741\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Little discovery in the laboratory: a new route for 25956-17-6 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Doguc, Duygu Kumbul; Deniz, Firdevs; Ilhan, Ilter; Ergonul, Esin; Gultekin, Fatih researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).Synthetic Route of C18H14N2Na2O8S2.They published the article \u300aPrenatal exposure to artificial food colorings alters NMDA receptor subunit concentrations in rat hippocampus\u300b about this compound( cas:25956-17-6 ) in Nutritional Neuroscience. Keywords: hippocampus NMDA receptor erythrosine tartrazine amaranth; Artificial food colors; NMDARs; NR2A; NR2B; forced swim test; open field test; spatial learning and memory; \u03b17 nAChR. We&#039;ll tell you more about this compound (cas:25956-17-6).\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=9741\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-04-19T20:14:06+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9741\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9741\",\"name\":\"Little discovery in the laboratory: a new route for 25956-17-6 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-04-19T20:14:06+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Doguc, Duygu Kumbul; Deniz, Firdevs; Ilhan, Ilter; Ergonul, Esin; Gultekin, Fatih researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).Synthetic Route of C18H14N2Na2O8S2.They published the article \u300aPrenatal exposure to artificial food colorings alters NMDA receptor subunit concentrations in rat hippocampus\u300b about this compound( cas:25956-17-6 ) in Nutritional Neuroscience. Keywords: hippocampus NMDA receptor erythrosine tartrazine amaranth; Artificial food colors; NMDARs; NR2A; NR2B; forced swim test; open field test; spatial learning and memory; \u03b17 nAChR. We'll tell you more about this compound (cas:25956-17-6).\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9741#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=9741\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9741#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Little discovery in the laboratory: a new route for 25956-17-6\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Little discovery in the laboratory: a new route for 25956-17-6 | pyrazoles-derivatives","description":"So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Doguc, Duygu Kumbul; Deniz, Firdevs; Ilhan, Ilter; Ergonul, Esin; Gultekin, Fatih researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).Synthetic Route of C18H14N2Na2O8S2.They published the article \u300aPrenatal exposure to artificial food colorings alters NMDA receptor subunit concentrations in rat hippocampus\u300b about this compound( cas:25956-17-6 ) in Nutritional Neuroscience. Keywords: hippocampus NMDA receptor erythrosine tartrazine amaranth; Artificial food colors; NMDARs; NR2A; NR2B; forced swim test; open field test; spatial learning and memory; \u03b17 nAChR. We'll tell you more about this compound (cas:25956-17-6).","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=9741","og_locale":"en_US","og_type":"article","og_title":"Little discovery in the laboratory: a new route for 25956-17-6 | pyrazoles-derivatives","og_description":"So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Doguc, Duygu Kumbul; Deniz, Firdevs; Ilhan, Ilter; Ergonul, Esin; Gultekin, Fatih researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).Synthetic Route of C18H14N2Na2O8S2.They published the article \u300aPrenatal exposure to artificial food colorings alters NMDA receptor subunit concentrations in rat hippocampus\u300b about this compound( cas:25956-17-6 ) in Nutritional Neuroscience. Keywords: hippocampus NMDA receptor erythrosine tartrazine amaranth; Artificial food colors; NMDARs; NR2A; NR2B; forced swim test; open field test; spatial learning and memory; \u03b17 nAChR. We'll tell you more about this compound (cas:25956-17-6).","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=9741","og_site_name":"pyrazoles-derivatives","article_published_time":"2022-04-19T20:14:06+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=9741","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=9741","name":"Little discovery in the laboratory: a new route for 25956-17-6 | pyrazoles-derivatives","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2022-04-19T20:14:06+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Doguc, Duygu Kumbul; Deniz, Firdevs; Ilhan, Ilter; Ergonul, Esin; Gultekin, Fatih researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).Synthetic Route of C18H14N2Na2O8S2.They published the article \u300aPrenatal exposure to artificial food colorings alters NMDA receptor subunit concentrations in rat hippocampus\u300b about this compound( cas:25956-17-6 ) in Nutritional Neuroscience. Keywords: hippocampus NMDA receptor erythrosine tartrazine amaranth; Artificial food colors; NMDARs; NR2A; NR2B; forced swim test; open field test; spatial learning and memory; \u03b17 nAChR. We'll tell you more about this compound (cas:25956-17-6).","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=9741#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=9741"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=9741#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Little discovery in the laboratory: a new route for 25956-17-6"}]},{"@type":"WebSite","@id":"https:\/\/www.pyrazoles-derivatives.com\/#website","url":"https:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1","name":"Jessica.F","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/","url":"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g","contentUrl":"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g","caption":"Jessica.F"}}]}},"_links":{"self":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts\/9741","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9741"}],"version-history":[{"count":0,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts\/9741\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9741"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9741"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}