{"id":9725,"date":"2022-04-20T04:14:06","date_gmt":"2022-04-19T20:14:06","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=9725"},"modified":"2022-04-20T04:14:06","modified_gmt":"2022-04-19T20:14:06","slug":"continuously-updated-synthesis-method-about-22600-77-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=9725","title":{"rendered":"Continuously updated synthesis method about 22600-77-7"},"content":{"rendered":"

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Chemistry of Bifunctional Photoprobes. 6. Synthesis and Characterization of High Specific Activity Metalated Photochemical Probes: Development of Novel Rhenium Photoconjugates of Human Serum Albumin and Fab Fragments, published in 2002-09-20, which mentions a compound: 22600-77-7, mainly applied to azathiaalkaneone azidofluorophenyl functionalized preparation; rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex preparation photolysis amine; human serum albumin labeling rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex; antibody labeling rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex, Computed Properties of C4H9Cl2N3<\/a>.<\/p>\n

Functionalization of perfluoro aryl azides by bifunctional chelating agents (BFCAs) capable of forming high specific activity complexes with 99mTc (for \u03b3-imaging) and 188Re (for radiotherapy) is described. The synthesis of multidonor BFCAs containing N2S2, N4, and N3S donor groups containing imidazole, pyridine, and pyrazine functionalities that may be important for tuning the pharmacokinetic parameters is also described. Functionalization of perfluoro aryl azides at various sites on BFCAs yields novel bifunctional photolabile chelating agents (BFPCAs) that are useful for covalent attachment to biomols. A representative Re-BFPCA I as the Me4N+ salt in a model solvent, diethylamine, proceeded to give a high yield of intermol. NH insertion product without the decomplexation of the metal ion from I. All products originated from the photolysis of I in diethylamine were characterized by anal. techniques, and a plausible mechanism of formation of different photolytic products is suggested. The high yield of intermol. NH insertion of I is extended to labeling of human serum albumin (HSA) and Fab fragments under aqueous conditions. The photolabeling technol. developed here offers a new way to attach diagnostically and therapeutically useful radiotracers (e.g., 99mTc, 188Re) to Fab fragments for potential noninvasive imaging and therapy of cancer.<\/p>\n

\u300aChemistry of Bifunctional Photoprobes. 6. Synthesis and Characterization of High Specific Activity Metalated Photochemical Probes: Development of Novel Rhenium Photoconjugates of Human Serum Albumin and Fab Fragments\u300b provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((1H-Imidazol-2-yl)methanamine dihydrochloride)Computed Properties of C4H9Cl2N3<\/a>.<\/p>\n

Reference:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/A><\/p>\n","protected":false},"excerpt":{"rendered":"

\u300aChemistry of Bifunctional Photoprobes. 6. Synthesis and Characterization of High Specific Activity Metalated Photochemical Probes: Development of Novel Rhenium Photoconjugates of Human Serum Albumin and Fab Fragments\u300b provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((1H-Imidazol-2-yl)methanamine dihydrochloride)Computed Properties of C4H9Cl2N3<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[730,131],"tags":[126],"class_list":["post-9725","post","type-post","status-publish","format-standard","hentry","category-22600-77-7","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nContinuously updated synthesis method about 22600-77-7 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Chemistry of Bifunctional Photoprobes. 6. Synthesis and Characterization of High Specific Activity Metalated Photochemical Probes: Development of Novel Rhenium Photoconjugates of Human Serum Albumin and Fab Fragments, published in 2002-09-20, which mentions a compound: 22600-77-7, mainly applied to azathiaalkaneone azidofluorophenyl functionalized preparation; rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex preparation photolysis amine; human serum albumin labeling rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex; antibody labeling rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex, Computed Properties of C4H9Cl2N3.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=9725\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Continuously updated synthesis method about 22600-77-7 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Chemistry of Bifunctional Photoprobes. 6. Synthesis and Characterization of High Specific Activity Metalated Photochemical Probes: Development of Novel Rhenium Photoconjugates of Human Serum Albumin and Fab Fragments, published in 2002-09-20, which mentions a compound: 22600-77-7, mainly applied to azathiaalkaneone azidofluorophenyl functionalized preparation; rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex preparation photolysis amine; human serum albumin labeling rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex; antibody labeling rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex, Computed Properties of C4H9Cl2N3.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=9725\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-04-19T20:14:06+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9725\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9725\",\"name\":\"Continuously updated synthesis method about 22600-77-7 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-04-19T20:14:06+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Chemistry of Bifunctional Photoprobes. 6. Synthesis and Characterization of High Specific Activity Metalated Photochemical Probes: Development of Novel Rhenium Photoconjugates of Human Serum Albumin and Fab Fragments, published in 2002-09-20, which mentions a compound: 22600-77-7, mainly applied to azathiaalkaneone azidofluorophenyl functionalized preparation; rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex preparation photolysis amine; human serum albumin labeling rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex; antibody labeling rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex, Computed Properties of C4H9Cl2N3.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9725#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=9725\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9725#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Continuously updated synthesis method about 22600-77-7\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Continuously updated synthesis method about 22600-77-7 | pyrazoles-derivatives","description":"In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Chemistry of Bifunctional Photoprobes. 6. Synthesis and Characterization of High Specific Activity Metalated Photochemical Probes: Development of Novel Rhenium Photoconjugates of Human Serum Albumin and Fab Fragments, published in 2002-09-20, which mentions a compound: 22600-77-7, mainly applied to azathiaalkaneone azidofluorophenyl functionalized preparation; rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex preparation photolysis amine; human serum albumin labeling rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex; antibody labeling rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex, Computed Properties of C4H9Cl2N3.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=9725","og_locale":"en_US","og_type":"article","og_title":"Continuously updated synthesis method about 22600-77-7 | pyrazoles-derivatives","og_description":"In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Chemistry of Bifunctional Photoprobes. 6. Synthesis and Characterization of High Specific Activity Metalated Photochemical Probes: Development of Novel Rhenium Photoconjugates of Human Serum Albumin and Fab Fragments, published in 2002-09-20, which mentions a compound: 22600-77-7, mainly applied to azathiaalkaneone azidofluorophenyl functionalized preparation; rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex preparation photolysis amine; human serum albumin labeling rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex; antibody labeling rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex, Computed Properties of C4H9Cl2N3.","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=9725","og_site_name":"pyrazoles-derivatives","article_published_time":"2022-04-19T20:14:06+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=9725","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=9725","name":"Continuously updated synthesis method about 22600-77-7 | pyrazoles-derivatives","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2022-04-19T20:14:06+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Chemistry of Bifunctional Photoprobes. 6. Synthesis and Characterization of High Specific Activity Metalated Photochemical Probes: Development of Novel Rhenium Photoconjugates of Human Serum Albumin and Fab Fragments, published in 2002-09-20, which mentions a compound: 22600-77-7, mainly applied to azathiaalkaneone azidofluorophenyl functionalized preparation; rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex preparation photolysis amine; human serum albumin labeling rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex; antibody labeling rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex, Computed Properties of C4H9Cl2N3.","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=9725#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=9725"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=9725#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Continuously updated synthesis method about 22600-77-7"}]},{"@type":"WebSite","@id":"https:\/\/www.pyrazoles-derivatives.com\/#website","url":"https:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1","name":"Jessica.F","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/","url":"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g","contentUrl":"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g","caption":"Jessica.F"}}]}},"_links":{"self":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts\/9725","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9725"}],"version-history":[{"count":0,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts\/9725\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9725"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9725"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9725"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}