{"id":9711,"date":"2022-04-19T04:46:24","date_gmt":"2022-04-18T20:46:24","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=9711"},"modified":"2022-04-19T04:46:24","modified_gmt":"2022-04-18T20:46:24","slug":"downstream-synthetic-route-of-17190-29-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=9711","title":{"rendered":"Downstream Synthetic Route Of 17190-29-3"},"content":{"rendered":"<p>The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ) is researched.<a href=\"https:\/\/www.ambeed.com\/products\/17190-29-3.html\">Application In Synthesis of  3-Hydroxy-3-phenylpropanenitrile<\/a>.Ma, Da-You; Wang, De-Xian; Pan, Jie; Huang, Zhi-Tang; Wang, Mei-Xiang published the article \u300aNitrile biotransformations for the synthesis of enantiomerically enriched \u03b22-, and \u03b23-hydroxy and -alkoxy acids and amides, a dramatic O-substituent effect of the substrates on enantioselectivity\u300b about this compound( cas:17190-29-3 )  in Tetrahedron: Asymmetry. Keywords: Rhodococcus nitrile hydratase biotransformation enantiomeric. Let&#8217;s learn more about this compound (cas:17190-29-3).<\/p>\n<p>Rhodococcus erythropolis AJ270, a nitrile hydratase\/amidase-containing microbial whole cell catalyst, is able to catalyze the hydrolysis of a number of \u03b2-hydroxy and \u03b2-alkoxy nitriles under very mild conditions. Both the efficiency and enantioselectivity of the biocatalysis, however, were strongly dependent upon the structures of both nitrile and amide substrates. When biotransformations of racemic 3-hydroxy-3-phenylpropionitrile and 2-hydroxymethyl-3-phenylpropionitrile gave low enantioselectivity, their O-methylated isomers underwent highly efficient and enantioselective biocatalytic reactions to afford highly enantioenriched \u03b22- and \u03b23-hydroxy amide and acid derivatives in excellent yield. The study has provided an example of simple and very convenient substrate engineering method to increase the enantioselectivity of the biocatalytic reaction.<\/p>\n<p>\u300aNitrile biotransformations for the synthesis of enantiomerically enriched \u03b22-, and \u03b23-hydroxy and -alkoxy acids and amides, a dramatic O-substituent effect of the substrates on enantioselectivity\u300b provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(3-Hydroxy-3-phenylpropanenitrile)<a href=\"https:\/\/www.ambeed.com\/products\/17190-29-3.html\">Application In Synthesis of  3-Hydroxy-3-phenylpropanenitrile<\/a>.<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/A><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u300aNitrile biotransformations for the synthesis of enantiomerically enriched \u03b22-, and \u03b23-hydroxy and -alkoxy acids and amides, a dramatic O-substituent effect of the substrates on enantioselectivity\u300b provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(3-Hydroxy-3-phenylpropanenitrile)<a href=\"https:\/\/www.ambeed.com\/products\/17190-29-3.html\">Application In Synthesis of  3-Hydroxy-3-phenylpropanenitrile<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[723,131],"tags":[126],"class_list":["post-9711","post","type-post","status-publish","format-standard","hentry","category-17190-29-3","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Downstream Synthetic Route Of 17190-29-3 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ) is researched.Application In Synthesis of 3-Hydroxy-3-phenylpropanenitrile.Ma, Da-You; Wang, De-Xian; Pan, Jie; Huang, Zhi-Tang; Wang, Mei-Xiang published the article \u300aNitrile biotransformations for the synthesis of enantiomerically enriched \u03b22-, and \u03b23-hydroxy and -alkoxy acids and amides, a dramatic O-substituent effect of the substrates on enantioselectivity\u300b about this compound( cas:17190-29-3 ) in Tetrahedron: Asymmetry. Keywords: Rhodococcus nitrile hydratase biotransformation enantiomeric. Let&#039;s learn more about this compound (cas:17190-29-3).\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=9711\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Downstream Synthetic Route Of 17190-29-3 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ) is researched.Application In Synthesis of 3-Hydroxy-3-phenylpropanenitrile.Ma, Da-You; Wang, De-Xian; Pan, Jie; Huang, Zhi-Tang; Wang, Mei-Xiang published the article \u300aNitrile biotransformations for the synthesis of enantiomerically enriched \u03b22-, and \u03b23-hydroxy and -alkoxy acids and amides, a dramatic O-substituent effect of the substrates on enantioselectivity\u300b about this compound( cas:17190-29-3 ) in Tetrahedron: Asymmetry. Keywords: Rhodococcus nitrile hydratase biotransformation enantiomeric. 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Compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ) is researched.Application In Synthesis of 3-Hydroxy-3-phenylpropanenitrile.Ma, Da-You; Wang, De-Xian; Pan, Jie; Huang, Zhi-Tang; Wang, Mei-Xiang published the article \u300aNitrile biotransformations for the synthesis of enantiomerically enriched \u03b22-, and \u03b23-hydroxy and -alkoxy acids and amides, a dramatic O-substituent effect of the substrates on enantioselectivity\u300b about this compound( cas:17190-29-3 ) in Tetrahedron: Asymmetry. Keywords: Rhodococcus nitrile hydratase biotransformation enantiomeric. 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Compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ) is researched.Application In Synthesis of 3-Hydroxy-3-phenylpropanenitrile.Ma, Da-You; Wang, De-Xian; Pan, Jie; Huang, Zhi-Tang; Wang, Mei-Xiang published the article \u300aNitrile biotransformations for the synthesis of enantiomerically enriched \u03b22-, and \u03b23-hydroxy and -alkoxy acids and amides, a dramatic O-substituent effect of the substrates on enantioselectivity\u300b about this compound( cas:17190-29-3 ) in Tetrahedron: Asymmetry. Keywords: Rhodococcus nitrile hydratase biotransformation enantiomeric. 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Compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ) is researched.Application In Synthesis of 3-Hydroxy-3-phenylpropanenitrile.Ma, Da-You; Wang, De-Xian; Pan, Jie; Huang, Zhi-Tang; Wang, Mei-Xiang published the article \u300aNitrile biotransformations for the synthesis of enantiomerically enriched \u03b22-, and \u03b23-hydroxy and -alkoxy acids and amides, a dramatic O-substituent effect of the substrates on enantioselectivity\u300b about this compound( cas:17190-29-3 ) in Tetrahedron: Asymmetry. Keywords: Rhodococcus nitrile hydratase biotransformation enantiomeric. Let's learn more about this compound (cas:17190-29-3).","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=9711","og_site_name":"pyrazoles-derivatives","article_published_time":"2022-04-18T20:46:24+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=9711","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=9711","name":"Downstream Synthetic Route Of 17190-29-3 | pyrazoles-derivatives","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2022-04-18T20:46:24+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ) is researched.Application In Synthesis of 3-Hydroxy-3-phenylpropanenitrile.Ma, Da-You; Wang, De-Xian; Pan, Jie; Huang, Zhi-Tang; Wang, Mei-Xiang published the article \u300aNitrile biotransformations for the synthesis of enantiomerically enriched \u03b22-, and \u03b23-hydroxy and -alkoxy acids and amides, a dramatic O-substituent effect of the substrates on enantioselectivity\u300b about this compound( cas:17190-29-3 ) in Tetrahedron: Asymmetry. Keywords: Rhodococcus nitrile hydratase biotransformation enantiomeric. 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