{"id":9697,"date":"2022-04-18T07:59:39","date_gmt":"2022-04-17T23:59:39","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=9697"},"modified":"2022-04-18T07:59:39","modified_gmt":"2022-04-17T23:59:39","slug":"a-new-synthetic-route-of-52287-51-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=9697","title":{"rendered":"A new synthetic route of 52287-51-1"},"content":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/52287-51-1.html\">Product Details of 52287-51-1<\/a>. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, is researched, Molecular C8H7BrO2, CAS is 52287-51-1, about gem-Difluoroallylation of Aryl Halides and Pseudo Halides with Difluoroallylboron Reagents in High Regioselectivity. Author is Sakamoto, Shu; Butcher, Trevor W.; Yang, Jonathan L.; Hartwig, John F..<\/p>\n<p>The palladium-catalyzed gem-difluoroallylation of aryl halides and pseudo halides Arx (X = Br, Cl, I, OTf; Ar = Ph, 4-tertbutylphenyl, 2,3-dihydro-1,4-benzodioxin-6-yl, etc.) and 4,4&#8242;-dibromo-2,2&#8242;-bithiophene with 3,3-difluoroallyl boronates F2C=C(R)CH(R1)BPin (R = H, nonyl, Ph, 1-benzofuran-2-yl, etc.; R1 = H, (benzyloxy)methyl) in high yield with high regioselectivity, and the preparation of the 3,3-difluoroallyl boronate reactants by a copper-catalyzed defluorinative borylation of inexpensive gaseous 3,3,3-trifluoropropene with bis(pinacolato)diboron were reported. The gem-difluoroallylation of aryl and heteroaryl bromides proceeds with low catalyst loading (0.1 mol% [Pd]) and tolerates a wide range of functional groups, including primary alcs., secondary amines, ethers, ketones, esters, amides, aldehydes, nitriles, halides, and nitro groups. This protocol extends to aryl iodides, chlorides, and triflates, as well as substituted difluoroallyl boronates, providing a versatile synthesis of gem-difluoroallyl arenes ArC(F2)C(R)=CHR1 that to be valuable intermediates to a series of fluorinated building blocks.<\/p>\n<p>Different reactions of this compound(6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine)<a href=\"https:\/\/www.ambeed.com\/products\/52287-51-1.html\">Product Details of 52287-51-1<\/a> require different conditions, so the reaction conditions are very important.<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/A><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Different reactions of this compound(6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine)<a href=\"https:\/\/www.ambeed.com\/products\/52287-51-1.html\">Product Details of 52287-51-1<\/a> require different conditions, so the reaction conditions are very important.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[725,131],"tags":[127],"class_list":["post-9697","post","type-post","status-publish","format-standard","hentry","category-52287-51-1","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A new synthetic route of 52287-51-1 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Product Details of 52287-51-1. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, is researched, Molecular C8H7BrO2, CAS is 52287-51-1, about gem-Difluoroallylation of Aryl Halides and Pseudo Halides with Difluoroallylboron Reagents in High Regioselectivity. Author is Sakamoto, Shu; Butcher, Trevor W.; Yang, Jonathan L.; Hartwig, John F..\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=9697\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new synthetic route of 52287-51-1 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Product Details of 52287-51-1. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, is researched, Molecular C8H7BrO2, CAS is 52287-51-1, about gem-Difluoroallylation of Aryl Halides and Pseudo Halides with Difluoroallylboron Reagents in High Regioselectivity. 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Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, is researched, Molecular C8H7BrO2, CAS is 52287-51-1, about gem-Difluoroallylation of Aryl Halides and Pseudo Halides with Difluoroallylboron Reagents in High Regioselectivity. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"http:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A new synthetic route of 52287-51-1 | pyrazoles-derivatives","description":"Product Details of 52287-51-1. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, is researched, Molecular C8H7BrO2, CAS is 52287-51-1, about gem-Difluoroallylation of Aryl Halides and Pseudo Halides with Difluoroallylboron Reagents in High Regioselectivity. Author is Sakamoto, Shu; Butcher, Trevor W.; Yang, Jonathan L.; Hartwig, John F..","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=9697","og_locale":"en_US","og_type":"article","og_title":"A new synthetic route of 52287-51-1 | pyrazoles-derivatives","og_description":"Product Details of 52287-51-1. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, is researched, Molecular C8H7BrO2, CAS is 52287-51-1, about gem-Difluoroallylation of Aryl Halides and Pseudo Halides with Difluoroallylboron Reagents in High Regioselectivity. 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Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, is researched, Molecular C8H7BrO2, CAS is 52287-51-1, about gem-Difluoroallylation of Aryl Halides and Pseudo Halides with Difluoroallylboron Reagents in High Regioselectivity. 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