{"id":9667,"date":"2022-04-15T04:01:15","date_gmt":"2022-04-14T20:01:15","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=9667"},"modified":"2022-04-15T04:01:15","modified_gmt":"2022-04-14T20:01:15","slug":"a-new-application-about-25956-17-6-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=9667","title":{"rendered":"A new application about 25956-17-6"},"content":{"rendered":"<p>Staples, Jack W.; Stine, Jessica M.; Maki-Lohiluoma, Eero; Steed, Emily; George, Kathleen M.; Thompson, Charles M.; Woodahl, Erica L. published the article \u300aFood dyes as P-glycoprotein modulators\u300b.  Keywords: allurared carmoisine ponceau4R sunset quinolone yellow tartrazine AtPase Pglycoprotein; Drug transporter; Food dye; P-glycoprotein.They  researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).<a href=\"https:\/\/www.ambeed.com\/products\/25956-17-6.html\">SDS of cas: 25956-17-6<\/a>. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:25956-17-6)  here.<\/p>\n<p>The drug transporter P-glycoprotein (P-gp) is often investigated in drug-interaction studies because the activity is modulated by a wide variety of xenobiotics including drugs, herbal products, and food components. In this study, we tested six common arylsulfonate food dyes-allura red, carmoisine, ponceau 4R, quinolone yellow, sunset yellow, and tartrazine-as activators and inhibitors of P-gp activity in vitro. The dyes were studied as P-gp activators by measuring ATPase activity in P-gp-expressing membranes. Compared to verapamil, a known activator of P-gp, the six food dyes showed no stimulatory activity. The potential for these six food dyes to act as P-gp inhibitors was tested in an intracellular efflux assay with P-gp-expressing cells. Compared to GF120918, a known P-gp inhibitor, there was no inhibitory activity for these six food dyes. The six food dyes tested do not interact with P-gp in vitro and, therefore, are unlikely cause clin. drug-food dye interactions. Further investigation is necessary to determine whether these food dyes could interact with other drug transporters.<\/p>\n<p>After consulting a lot of data, we found that this compound(25956-17-6)<a href=\"https:\/\/www.ambeed.com\/products\/25956-17-6.html\">SDS of cas: 25956-17-6<\/a> can be used in many types of reactions. And in most cases, this compound has more advantages.<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/A><\/p>\n","protected":false},"excerpt":{"rendered":"<p>After consulting a lot of data, we found that this compound(25956-17-6)<a href=\"https:\/\/www.ambeed.com\/products\/25956-17-6.html\">SDS of cas: 25956-17-6<\/a> can be used in many types of reactions. And in most cases, this compound has more advantages.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[727,131],"tags":[500],"class_list":["post-9667","post","type-post","status-publish","format-standard","hentry","category-25956-17-6","category-pyrazoles-derivatives","tag-m-w400-500"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A new application about 25956-17-6 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Staples, Jack W.; Stine, Jessica M.; Maki-Lohiluoma, Eero; Steed, Emily; George, Kathleen M.; Thompson, Charles M.; Woodahl, Erica L. published the article \u300aFood dyes as P-glycoprotein modulators\u300b. Keywords: allurared carmoisine ponceau4R sunset quinolone yellow tartrazine AtPase Pglycoprotein; Drug transporter; Food dye; P-glycoprotein.They researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).SDS of cas: 25956-17-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:25956-17-6) here.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=9667\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new application about 25956-17-6 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Staples, Jack W.; Stine, Jessica M.; Maki-Lohiluoma, Eero; Steed, Emily; George, Kathleen M.; Thompson, Charles M.; Woodahl, Erica L. published the article \u300aFood dyes as P-glycoprotein modulators\u300b. Keywords: allurared carmoisine ponceau4R sunset quinolone yellow tartrazine AtPase Pglycoprotein; Drug transporter; Food dye; P-glycoprotein.They researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).SDS of cas: 25956-17-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:25956-17-6) here.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=9667\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-04-14T20:01:15+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9667\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9667\",\"name\":\"A new application about 25956-17-6 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-04-14T20:01:15+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Staples, Jack W.; Stine, Jessica M.; Maki-Lohiluoma, Eero; Steed, Emily; George, Kathleen M.; Thompson, Charles M.; Woodahl, Erica L. published the article \u300aFood dyes as P-glycoprotein modulators\u300b. Keywords: allurared carmoisine ponceau4R sunset quinolone yellow tartrazine AtPase Pglycoprotein; Drug transporter; Food dye; P-glycoprotein.They researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).SDS of cas: 25956-17-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A new application about 25956-17-6 | pyrazoles-derivatives","description":"Staples, Jack W.; Stine, Jessica M.; Maki-Lohiluoma, Eero; Steed, Emily; George, Kathleen M.; Thompson, Charles M.; Woodahl, Erica L. published the article \u300aFood dyes as P-glycoprotein modulators\u300b. Keywords: allurared carmoisine ponceau4R sunset quinolone yellow tartrazine AtPase Pglycoprotein; Drug transporter; Food dye; P-glycoprotein.They researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).SDS of cas: 25956-17-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:25956-17-6) here.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=9667","og_locale":"en_US","og_type":"article","og_title":"A new application about 25956-17-6 | pyrazoles-derivatives","og_description":"Staples, Jack W.; Stine, Jessica M.; Maki-Lohiluoma, Eero; Steed, Emily; George, Kathleen M.; Thompson, Charles M.; Woodahl, Erica L. published the article \u300aFood dyes as P-glycoprotein modulators\u300b. Keywords: allurared carmoisine ponceau4R sunset quinolone yellow tartrazine AtPase Pglycoprotein; Drug transporter; Food dye; P-glycoprotein.They researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).SDS of cas: 25956-17-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:25956-17-6) here.","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=9667","og_site_name":"pyrazoles-derivatives","article_published_time":"2022-04-14T20:01:15+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=9667","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=9667","name":"A new application about 25956-17-6 | pyrazoles-derivatives","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2022-04-14T20:01:15+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Staples, Jack W.; Stine, Jessica M.; Maki-Lohiluoma, Eero; Steed, Emily; George, Kathleen M.; Thompson, Charles M.; Woodahl, Erica L. published the article \u300aFood dyes as P-glycoprotein modulators\u300b. Keywords: allurared carmoisine ponceau4R sunset quinolone yellow tartrazine AtPase Pglycoprotein; Drug transporter; Food dye; P-glycoprotein.They researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).SDS of cas: 25956-17-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. 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