{"id":9643,"date":"2022-04-13T10:20:33","date_gmt":"2022-04-13T02:20:33","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=9643"},"modified":"2022-04-13T10:20:33","modified_gmt":"2022-04-13T02:20:33","slug":"never-underestimate-the-influence-of-52287-51-1-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=9643","title":{"rendered":"Never Underestimate the Influence Of 52287-51-1"},"content":{"rendered":"<p>Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 52287-51-1, is researched, SMILESS is BrC1=CC=C2OCCOC2=C1, Molecular C8H7BrO2Journal, Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov&#8217;t, Non-P.H.S., Journal of the American Chemical Society called Generation of Axially Chiral Fluoroallenes through a Copper-Catalyzed Enantioselective \u03b2-Fluoride Elimination, Author is O&#8217;Connor, Thomas J.; Mai, Binh Khanh; Nafie, Jordan; Liu, Peng; Toste, F. Dean, the main research direction is axial chiral fluoroallene preparation; copper catalyst enantioselective fluoride elimination Josiphos ligand preparation; mol structure optimized chiral ferrocene phosphine propargyl difluoride DFT; silylation catalyst ferrocene chiral Josiphos propargylic difluoride stereoselective mechanism.<a href=\"https:\/\/www.ambeed.com\/products\/52287-51-1.html\">Electric Literature of C8H7BrO2<\/a>.<\/p>\n<p>Herein we report the copper-catalyzed silylation of propargylic difluorides to generate axially chiral, tetrasubstituted monofluoroallenes in both good yields (27 examples >80%) and enantioselectivities (82-98% ee). Compared to previously reported synthetic routes to axially chiral allenes (ACAs) from prochiral substrates, a mechanistically distinct reaction has been developed: the enantiodiscrimination between enantiotopic fluorides to set an axial stereocenter. DFT calculations and vibrational CD (VCD) suggest that \u03b2-fluoride elimination from an alkenyl copper intermediate likely proceeds through a syn-\u03b2-fluoride elimination pathway rather than an anti-elimination pathway. The effects of the C1-sym. Josiphos-derived ligand on reactivity and enantioselectivity were investigated. Not only does this report showcase that alkenyl copper species (like their alkyl counterparts) can undergo \u03b2-fluoride elimination, but this elimination can be achieved in an enantioselective fashion.<\/p>\n<p>Although many compounds look similar to this compound(52287-51-1)<a href=\"https:\/\/www.ambeed.com\/products\/52287-51-1.html\">Electric Literature of C8H7BrO2<\/a>, numerous studies have shown that this compound(SMILES:BrC1=CC=C2OCCOC2=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/A><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Although many compounds look similar to this compound(52287-51-1)<a href=\"https:\/\/www.ambeed.com\/products\/52287-51-1.html\">Electric Literature of C8H7BrO2<\/a>, numerous studies have shown that this compound(SMILES:BrC1=CC=C2OCCOC2=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[725,131],"tags":[127],"class_list":["post-9643","post","type-post","status-publish","format-standard","hentry","category-52287-51-1","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Never Underestimate the Influence Of 52287-51-1 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 52287-51-1, is researched, SMILESS is BrC1=CC=C2OCCOC2=C1, Molecular C8H7BrO2Journal, Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov&#039;t, Non-P.H.S., Journal of the American Chemical Society called Generation of Axially Chiral Fluoroallenes through a Copper-Catalyzed Enantioselective \u03b2-Fluoride Elimination, Author is O&#039;Connor, Thomas J.; Mai, Binh Khanh; Nafie, Jordan; Liu, Peng; Toste, F. Dean, the main research direction is axial chiral fluoroallene preparation; copper catalyst enantioselective fluoride elimination Josiphos ligand preparation; mol structure optimized chiral ferrocene phosphine propargyl difluoride DFT; silylation catalyst ferrocene chiral Josiphos propargylic difluoride stereoselective mechanism.Electric Literature of C8H7BrO2.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=9643\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Never Underestimate the Influence Of 52287-51-1 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 52287-51-1, is researched, SMILESS is BrC1=CC=C2OCCOC2=C1, Molecular C8H7BrO2Journal, Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov&#039;t, Non-P.H.S., Journal of the American Chemical Society called Generation of Axially Chiral Fluoroallenes through a Copper-Catalyzed Enantioselective \u03b2-Fluoride Elimination, Author is O&#039;Connor, Thomas J.; Mai, Binh Khanh; Nafie, Jordan; Liu, Peng; Toste, F. Dean, the main research direction is axial chiral fluoroallene preparation; copper catalyst enantioselective fluoride elimination Josiphos ligand preparation; mol structure optimized chiral ferrocene phosphine propargyl difluoride DFT; silylation catalyst ferrocene chiral Josiphos propargylic difluoride stereoselective mechanism.Electric Literature of C8H7BrO2.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=9643\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-04-13T02:20:33+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9643\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9643\",\"name\":\"Never Underestimate the Influence Of 52287-51-1 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-04-13T02:20:33+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 52287-51-1, is researched, SMILESS is BrC1=CC=C2OCCOC2=C1, Molecular C8H7BrO2Journal, Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S., Journal of the American Chemical Society called Generation of Axially Chiral Fluoroallenes through a Copper-Catalyzed Enantioselective \u03b2-Fluoride Elimination, Author is O'Connor, Thomas J.; Mai, Binh Khanh; Nafie, Jordan; Liu, Peng; Toste, F. Dean, the main research direction is axial chiral fluoroallene preparation; copper catalyst enantioselective fluoride elimination Josiphos ligand preparation; mol structure optimized chiral ferrocene phosphine propargyl difluoride DFT; silylation catalyst ferrocene chiral Josiphos propargylic difluoride stereoselective mechanism.Electric Literature of C8H7BrO2.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9643#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=9643\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9643#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Never Underestimate the Influence Of 52287-51-1\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Never Underestimate the Influence Of 52287-51-1 | pyrazoles-derivatives","description":"Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 52287-51-1, is researched, SMILESS is BrC1=CC=C2OCCOC2=C1, Molecular C8H7BrO2Journal, Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S., Journal of the American Chemical Society called Generation of Axially Chiral Fluoroallenes through a Copper-Catalyzed Enantioselective \u03b2-Fluoride Elimination, Author is O'Connor, Thomas J.; Mai, Binh Khanh; Nafie, Jordan; Liu, Peng; Toste, F. Dean, the main research direction is axial chiral fluoroallene preparation; copper catalyst enantioselective fluoride elimination Josiphos ligand preparation; mol structure optimized chiral ferrocene phosphine propargyl difluoride DFT; silylation catalyst ferrocene chiral Josiphos propargylic difluoride stereoselective mechanism.Electric Literature of C8H7BrO2.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=9643","og_locale":"en_US","og_type":"article","og_title":"Never Underestimate the Influence Of 52287-51-1 | pyrazoles-derivatives","og_description":"Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 52287-51-1, is researched, SMILESS is BrC1=CC=C2OCCOC2=C1, Molecular C8H7BrO2Journal, Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S., Journal of the American Chemical Society called Generation of Axially Chiral Fluoroallenes through a Copper-Catalyzed Enantioselective \u03b2-Fluoride Elimination, Author is O'Connor, Thomas J.; Mai, Binh Khanh; Nafie, Jordan; Liu, Peng; Toste, F. Dean, the main research direction is axial chiral fluoroallene preparation; copper catalyst enantioselective fluoride elimination Josiphos ligand preparation; mol structure optimized chiral ferrocene phosphine propargyl difluoride DFT; silylation catalyst ferrocene chiral Josiphos propargylic difluoride stereoselective mechanism.Electric Literature of C8H7BrO2.","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=9643","og_site_name":"pyrazoles-derivatives","article_published_time":"2022-04-13T02:20:33+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=9643","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=9643","name":"Never Underestimate the Influence Of 52287-51-1 | pyrazoles-derivatives","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2022-04-13T02:20:33+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 52287-51-1, is researched, SMILESS is BrC1=CC=C2OCCOC2=C1, Molecular C8H7BrO2Journal, Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S., Journal of the American Chemical Society called Generation of Axially Chiral Fluoroallenes through a Copper-Catalyzed Enantioselective \u03b2-Fluoride Elimination, Author is O'Connor, Thomas J.; Mai, Binh Khanh; Nafie, Jordan; Liu, Peng; Toste, F. Dean, the main research direction is axial chiral fluoroallene preparation; copper catalyst enantioselective fluoride elimination Josiphos ligand preparation; mol structure optimized chiral ferrocene phosphine propargyl difluoride DFT; silylation catalyst ferrocene chiral Josiphos propargylic difluoride stereoselective mechanism.Electric Literature of C8H7BrO2.","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=9643#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=9643"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=9643#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Never Underestimate the Influence Of 52287-51-1"}]},{"@type":"WebSite","@id":"https:\/\/www.pyrazoles-derivatives.com\/#website","url":"https:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1","name":"Jessica.F","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/","url":"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g","contentUrl":"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g","caption":"Jessica.F"}}]}},"_links":{"self":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts\/9643","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9643"}],"version-history":[{"count":0,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts\/9643\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9643"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9643"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9643"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}