{"id":9622,"date":"2022-04-12T08:51:32","date_gmt":"2022-04-12T00:51:32","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=9622"},"modified":"2022-04-12T08:51:32","modified_gmt":"2022-04-12T00:51:32","slug":"a-new-application-about-17190-29-3-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=9622","title":{"rendered":"A new application about 17190-29-3"},"content":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/17190-29-3.html\">Recommanded Product: 3-Hydroxy-3-phenylpropanenitrile<\/a>. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Catalytic reduction of the nitriles of \u03b2,\u03b2-pentamethyleneglycidic, trans-\u03b2-phenylglycidic, and \u03b2-methyl-\u03b2-phenylglycidic acids on Raney nickel. Author is Martynov, V. F.; Shchelkunov, A. V..<\/p>\n<p>The title nitriles I, II, and III treated with H2O2 in alk. aqueous-alc. media give the corresponding amides (IV), hydrogenated on usual-activity Raney Ni (prepared without use of pressure) give the corresponding hydroxy compounds RR1C(OH)CH2CN (V), and hydrogenated on high-activity Raney Ni (prepared under pressure) give the corresponding hydroxy amino compounds RR1C(OH)CH2CH2NH2 (VI). A mixture of 0.47 g I, 5 ml EtOH, 5 ml 2N NaOH, and 1 ml 30% H2O2 heated at 60-70\u00b0 (until the evolution of O ceased) gave 0.34 g IV [(R r1 =) pentamethylene]. Similarly, 0.4 g II, 8 ml EtOH, 5 ml 2N NaOH, and 2.5 ml 30% H2 o2 gave 0.26 g IV (R = H, R1 = Ph), and 0.75 g III, 15 ml EtOH , 6 ml 2N NaOH, and 3 ml 30% H2O2 gave 0.41 g IV (R = Me, R1 = Ph). I (3.14 g) hydrogenated on 0.43 g of a com. high-activity Raney Ni catalyst in 25 ml 96% EtOH at 23\u00b0\/761.8 mm 7 hr (1598 ml H absorbed), 2.8 g Ac2O added to the filtrate remaining on catalyst removal, and the mixt . stirred until the heat evolution ceased gave 1.55 g VI [(RR1 =)-pentamethylene] N-monacetyl derivative (cf. Stork, CA 55:2594h). I (2.6 g) hydrogenated on 0.31 g usual-activity Raney Ni catalyst in 20 ml 96% EtOH at 18\u00b0\/758.4 mm 3 hr (443 ml H absorbed) gave 1.77 g V [(RR1 =) pentamethylene] (VII), b4 113-14\u00b0. VII treated with H2O2 as above gave VIIa. II (4.35 g) hydrogenated on 0.43 g usual-activity Raney Ni catalyst i n 15 ml 96% EtOH at 16\u00b0\/759.3 mm 3 hr (693 ml H absorbed), and the mix t. treated as above gave 2.65 g V (R = H, R1 = Ph) (VIII). VIII treated with H2O2 gave PhCH(OH)CH2CONH2. III (2.73 g) hydrogenated on 0.33 g usual-activity Raney Ni catalyst in 15 ml 96% EtOH at 18\u00b0\/769.2 mm 2.5 hr (388 ml H absorbed), and treated in alkali with 30% H2O2 yielded 2.26 g MeCPh(OH)CH2CONH2.<\/p>\n<p>Compounds in my other articles are similar to this one(3-Hydroxy-3-phenylpropanenitrile)<a href=\"https:\/\/www.ambeed.com\/products\/17190-29-3.html\">Recommanded Product: 3-Hydroxy-3-phenylpropanenitrile<\/a>, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/A><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Compounds in my other articles are similar to this one(3-Hydroxy-3-phenylpropanenitrile)<a href=\"https:\/\/www.ambeed.com\/products\/17190-29-3.html\">Recommanded Product: 3-Hydroxy-3-phenylpropanenitrile<\/a>, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[723,131],"tags":[126],"class_list":["post-9622","post","type-post","status-publish","format-standard","hentry","category-17190-29-3","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A new application about 17190-29-3 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Recommanded Product: 3-Hydroxy-3-phenylpropanenitrile. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Catalytic reduction of the nitriles of \u03b2,\u03b2-pentamethyleneglycidic, trans-\u03b2-phenylglycidic, and \u03b2-methyl-\u03b2-phenylglycidic acids on Raney nickel. Author is Martynov, V. F.; Shchelkunov, A. 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Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Catalytic reduction of the nitriles of \u03b2,\u03b2-pentamethyleneglycidic, trans-\u03b2-phenylglycidic, and \u03b2-methyl-\u03b2-phenylglycidic acids on Raney nickel. Author is Martynov, V. F.; Shchelkunov, A. 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Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Catalytic reduction of the nitriles of \u03b2,\u03b2-pentamethyleneglycidic, trans-\u03b2-phenylglycidic, and \u03b2-methyl-\u03b2-phenylglycidic acids on Raney nickel. Author is Martynov, V. F.; Shchelkunov, A. V..","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=9622","og_locale":"en_US","og_type":"article","og_title":"A new application about 17190-29-3 | pyrazoles-derivatives","og_description":"Recommanded Product: 3-Hydroxy-3-phenylpropanenitrile. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Catalytic reduction of the nitriles of \u03b2,\u03b2-pentamethyleneglycidic, trans-\u03b2-phenylglycidic, and \u03b2-methyl-\u03b2-phenylglycidic acids on Raney nickel. Author is Martynov, V. F.; Shchelkunov, A. 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Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Catalytic reduction of the nitriles of \u03b2,\u03b2-pentamethyleneglycidic, trans-\u03b2-phenylglycidic, and \u03b2-methyl-\u03b2-phenylglycidic acids on Raney nickel. Author is Martynov, V. F.; Shchelkunov, A. 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