{"id":960,"date":"2020-11-06T10:45:15","date_gmt":"2020-11-06T02:45:15","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=960"},"modified":"2020-11-06T10:45:15","modified_gmt":"2020-11-06T02:45:15","slug":"extended-knowledge-of-34-dimethyl-1h-pyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=960","title":{"rendered":"Extended knowledge of 3,4-Dimethyl-1H-pyrazole"},"content":{"rendered":"

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2820-37-3 as follows. 2820-37-3<\/a><\/p>\n

To a solution of crude reactant (249.5 mg, 0.629 mmol, theoretical amount) in anhydrous THF (5 mL) was added 3.4-dimethyl-lH-pyrazole (120.7 mg, 1.256 mmol) followed by potassium carbonate (173.6 mg, 1.256 mmol). The solution was stirred at 25 C overnight then the solution was diluted with ethyl acetate (200 mL). The resulting solution was washed with brine (2x100mL), dried over magnesium sulfate and concentrated in vacuo. The crude product was purified by silica gel chromatography (petroleum ether\/ ethyl acetate =1 :3) to afford product (56 mg, 0.136 mmol, Yield=22% (2 steps)) as white solid. 1HNMR (400 MHz, CDC13) 5(ppm): 7.08 (1H, s), 4.77 (1H, AB), 4.76 (1H, AB), 2.55 (1H, t), 2.18 (3H, s), 1.00-2.20 (24H, m).0.67 (3H, s). LCMS: rt = 2.41 mm, m\/z = 413.2 [M+H]+<\/p>\n

According to the analysis of related databases, 2820-37-3, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 2820-37-3, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[194,131],"tags":[145],"class_list":["post-960","post","type-post","status-publish","format-standard","hentry","category-2820-37-3","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nExtended knowledge of 3,4-Dimethyl-1H-pyrazole<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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