{"id":9590,"date":"2022-04-11T04:48:22","date_gmt":"2022-04-10T20:48:22","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=9590"},"modified":"2022-04-11T04:48:22","modified_gmt":"2022-04-10T20:48:22","slug":"research-on-new-synthetic-routes-about-25956-17-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=9590","title":{"rendered":"Research on new synthetic routes about 25956-17-6"},"content":{"rendered":"<p>Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 25956-17-6, is researched, Molecular C18H14N2Na2O8S2, about Toxicity Assessment of 4 Azo Dyes in Zebrafish Embryos, the main research direction is Danio tartrazine amaranth Allura red azo dyes embryo toxicity; azo dyes; color additives; developmental toxicity; zebrafish.<a href=\"https:\/\/www.ambeed.com\/products\/25956-17-6.html\">SDS of cas: 25956-17-6<\/a>.<\/p>\n<p>Azo dyes are used widely as color additives in food, drugs, and cosmetics; hence, there is an increasing concern about their safety and possible health hazards. In the present study, we chose 4 azo dyes tartrazine, Sunset Yellow, amaranth, and Allura red and evaluated their developmental toxicity on zebrafish embryos. At concentration levels of 5 to 50 mM, we found that azo dyes can induce hatching difficulty and developmental abnormalities such as cardiac edema, decreased heart rate, yolk sac edema, and spinal defects including spinal curvature and tail distortion. Exposure to 100 mM of each azo dye was completely embryolethal. The median lethal concentration (LC50), median effective concentration (EC50), and teratogenic index (TI) were calculated for each azo dye at 72 h postfertilization. For tartrazine, the LC50 was 47.10 mM and EC50 value was at 42.66 mM with TI ratio of 1.10. For Sunset Yellow, the LC50 was 38.93 mM and EC50 value was at 29.81 mM with TI ratio of 1.31. For amaranth, the LC50 was 39.86 mM and EC50 value was at 31.94 mM with TI ratio of 1.25. For Allura red, the LC50 was 47.42 mM and EC50 value was 40.05 mM with TI ratio of 1.18. This study reports the developmental toxicity of azo dyes in zebrafish embryos at concentrations higher than the expected human exposures from consuming food and drugs containing azo dyes.<\/p>\n<p>In addition to the literature in the link below, there is a lot of literature about this compound(Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate)<a href=\"https:\/\/www.ambeed.com\/products\/25956-17-6.html\">SDS of cas: 25956-17-6<\/a>, illustrating the importance and wide applicability of this compound(25956-17-6).<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/A><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In addition to the literature in the link below, there is a lot of literature about this compound(Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate)<a href=\"https:\/\/www.ambeed.com\/products\/25956-17-6.html\">SDS of cas: 25956-17-6<\/a>, illustrating the importance and wide applicability of this compound(25956-17-6).<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[727,131],"tags":[500],"class_list":["post-9590","post","type-post","status-publish","format-standard","hentry","category-25956-17-6","category-pyrazoles-derivatives","tag-m-w400-500"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research on new synthetic routes about 25956-17-6 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 25956-17-6, is researched, Molecular C18H14N2Na2O8S2, about Toxicity Assessment of 4 Azo Dyes in Zebrafish Embryos, the main research direction is Danio tartrazine amaranth Allura red azo dyes embryo toxicity; azo dyes; color additives; developmental toxicity; zebrafish.SDS of cas: 25956-17-6.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=9590\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research on new synthetic routes about 25956-17-6 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 25956-17-6, is researched, Molecular C18H14N2Na2O8S2, about Toxicity Assessment of 4 Azo Dyes in Zebrafish Embryos, the main research direction is Danio tartrazine amaranth Allura red azo dyes embryo toxicity; azo dyes; color additives; developmental toxicity; zebrafish.SDS of cas: 25956-17-6.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=9590\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-04-10T20:48:22+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9590\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9590\",\"name\":\"Research on new synthetic routes about 25956-17-6 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-04-10T20:48:22+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 25956-17-6, is researched, Molecular C18H14N2Na2O8S2, about Toxicity Assessment of 4 Azo Dyes in Zebrafish Embryos, the main research direction is Danio tartrazine amaranth Allura red azo dyes embryo toxicity; azo dyes; color additives; developmental toxicity; zebrafish.SDS of cas: 25956-17-6.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9590#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=9590\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9590#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research on new synthetic routes about 25956-17-6\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/cn.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/cn.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Research on new synthetic routes about 25956-17-6 | pyrazoles-derivatives","description":"Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 25956-17-6, is researched, Molecular C18H14N2Na2O8S2, about Toxicity Assessment of 4 Azo Dyes in Zebrafish Embryos, the main research direction is Danio tartrazine amaranth Allura red azo dyes embryo toxicity; azo dyes; color additives; developmental toxicity; zebrafish.SDS of cas: 25956-17-6.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=9590","og_locale":"en_US","og_type":"article","og_title":"Research on new synthetic routes about 25956-17-6 | pyrazoles-derivatives","og_description":"Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. 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