{"id":9562,"date":"2022-04-08T05:13:06","date_gmt":"2022-04-07T21:13:06","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=9562"},"modified":"2022-04-08T05:13:06","modified_gmt":"2022-04-07T21:13:06","slug":"share-an-extended-knowledge-of-a-compound-25956-17-6-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=9562","title":{"rendered":"Share an extended knowledge of a compound : 25956-17-6"},"content":{"rendered":"<p>The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ) is researched.<a href=\"https:\/\/www.ambeed.com\/products\/25956-17-6.html\">COA of Formula: C18H14N2Na2O8S2<\/a>.Dinc-Zor, Sule; Donmez, Ozlem Aksu; Asci, Burge; Pingo, Evridiki published the article \u300aChemometric optimization of an HPLC method for the simultaneous analysis of a multi component drug product by the help of central composite design\u300b about this compound( cas:25956-17-6 )  in Microchemical Journal. Keywords: syrup paracetamol doxylamine succinate saccharine HPLC chemometrics CCD. Let&#8217;s learn more about this compound (cas:25956-17-6).<\/p>\n<p>In this study, a simple, accurate, precise and rapid HPLC method was developed for the simultaneous quantification of paracetamol (PAR), pseudoephedrine hydrochloride (PSE), dextromethorphan hydrobromide (DEX) and doxylamine succinate (DOX) along with colorants; allura red (AR) and brilliant blue (BB) and sweetener; saccharine (SAC) in a syrup sample. Three indepented variables considered and their levels in Central Composite Design in order to optimize chromatog. separation conditions were as follows: Phosphate buffer ratio in mobile phase in the first gradient elution (GR1; 67, 70, 75, 80 and 83%), phosphate buffer ratio in mobile phase in the second gradient elution (GR2; 27, 30, 35, 40 and 43%) and flow rate of the mobile phase (FR; 0.9, 1.0, 1.2, 1.4 and 1.5 mL\/min). Critical resolution values between SAC, PAR and PSE along with between AR and BB were used as a response. Chromatog. separation was achieved using reversed phase C18 column (4.6 mm \u00d7 250 mm \u00d7 5\u03bcm particle size) and the six analytes were detected with a diode array detector at 210 nm. As per the results of the optimization procedure, these optimum variables were found to be flow rate, 1.4 mL\/min, phosphate buffer ratios in mobile phase in the first and second gradient elution, 75 and 40%, resp. After optimization step, the developed method was validated in compliance with ICH guideline. Finally, the method was successfully applied to the simultaneous quantification of PAR, PSE, DEX, DOX, AR, BB and SAC in a com. syrup sample.<\/p>\n<p>I hope my short article helps more people learn about this compound(Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate)<a href=\"https:\/\/www.ambeed.com\/products\/25956-17-6.html\">COA of Formula: C18H14N2Na2O8S2<\/a>. Apart from the compound(25956-17-6), you can read my other articles to know other related compounds.<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/A><\/p>\n","protected":false},"excerpt":{"rendered":"<p>I hope my short article helps more people learn about this compound(Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate)<a href=\"https:\/\/www.ambeed.com\/products\/25956-17-6.html\">COA of Formula: C18H14N2Na2O8S2<\/a>. Apart from the compound(25956-17-6), you can read my other articles to know other related compounds.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[727,131],"tags":[500],"class_list":["post-9562","post","type-post","status-publish","format-standard","hentry","category-25956-17-6","category-pyrazoles-derivatives","tag-m-w400-500"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Share an extended knowledge of a compound : 25956-17-6 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ) is researched.COA of Formula: C18H14N2Na2O8S2.Dinc-Zor, Sule; Donmez, Ozlem Aksu; Asci, Burge; Pingo, Evridiki published the article \u300aChemometric optimization of an HPLC method for the simultaneous analysis of a multi component drug product by the help of central composite design\u300b about this compound( cas:25956-17-6 ) in Microchemical Journal. Keywords: syrup paracetamol doxylamine succinate saccharine HPLC chemometrics CCD. 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Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ) is researched.COA of Formula: C18H14N2Na2O8S2.Dinc-Zor, Sule; Donmez, Ozlem Aksu; Asci, Burge; Pingo, Evridiki published the article \u300aChemometric optimization of an HPLC method for the simultaneous analysis of a multi component drug product by the help of central composite design\u300b about this compound( cas:25956-17-6 ) in Microchemical Journal. Keywords: syrup paracetamol doxylamine succinate saccharine HPLC chemometrics CCD. 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Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ) is researched.COA of Formula: C18H14N2Na2O8S2.Dinc-Zor, Sule; Donmez, Ozlem Aksu; Asci, Burge; Pingo, Evridiki published the article \u300aChemometric optimization of an HPLC method for the simultaneous analysis of a multi component drug product by the help of central composite design\u300b about this compound( cas:25956-17-6 ) in Microchemical Journal. Keywords: syrup paracetamol doxylamine succinate saccharine HPLC chemometrics CCD. 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Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ) is researched.COA of Formula: C18H14N2Na2O8S2.Dinc-Zor, Sule; Donmez, Ozlem Aksu; Asci, Burge; Pingo, Evridiki published the article \u300aChemometric optimization of an HPLC method for the simultaneous analysis of a multi component drug product by the help of central composite design\u300b about this compound( cas:25956-17-6 ) in Microchemical Journal. Keywords: syrup paracetamol doxylamine succinate saccharine HPLC chemometrics CCD. 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Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ) is researched.COA of Formula: C18H14N2Na2O8S2.Dinc-Zor, Sule; Donmez, Ozlem Aksu; Asci, Burge; Pingo, Evridiki published the article \u300aChemometric optimization of an HPLC method for the simultaneous analysis of a multi component drug product by the help of central composite design\u300b about this compound( cas:25956-17-6 ) in Microchemical Journal. Keywords: syrup paracetamol doxylamine succinate saccharine HPLC chemometrics CCD. Let's learn more about this compound (cas:25956-17-6).","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=9562","og_site_name":"pyrazoles-derivatives","article_published_time":"2022-04-07T21:13:06+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=9562","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=9562","name":"Share an extended knowledge of a compound : 25956-17-6 | pyrazoles-derivatives","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2022-04-07T21:13:06+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ) is researched.COA of Formula: C18H14N2Na2O8S2.Dinc-Zor, Sule; Donmez, Ozlem Aksu; Asci, Burge; Pingo, Evridiki published the article \u300aChemometric optimization of an HPLC method for the simultaneous analysis of a multi component drug product by the help of central composite design\u300b about this compound( cas:25956-17-6 ) in Microchemical Journal. Keywords: syrup paracetamol doxylamine succinate saccharine HPLC chemometrics CCD. 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