{"id":9540,"date":"2022-04-07T11:11:27","date_gmt":"2022-04-07T03:11:27","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=9540"},"modified":"2022-04-07T11:11:27","modified_gmt":"2022-04-07T03:11:27","slug":"share-an-extended-knowledge-of-a-compound-25956-17-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=9540","title":{"rendered":"Share an extended knowledge of a compound : 25956-17-6"},"content":{"rendered":"

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zou, Ling; Pottel, Joshua; Khuri, Natalia; Ngo, Huy X.; Ni, Zhanglin; Tsakalozou, Eleftheria; Warren, Mark S.; Huang, Yong; Shoichet, Brian K.; Giacomini, Kathleen M. researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).Computed Properties of C18H14N2Na2O8S2<\/a>.They published the article \u300aInteractions of Oral Molecular Excipients with Breast Cancer Resistance Protein, BCRP\u300b about this compound( cas:25956-17-6 ) in Molecular Pharmaceutics. Keywords: BCRP excipient; BCRP; drug\u2212excipient interaction; excipient. We’ll tell you more about this compound (cas:25956-17-6).<\/p>\n

Mechanistic-understanding-based selection of excipients may improve formulation development strategies for generic drug products and potentially accelerate their approval. Our study aimed at investigating the effects of mol. excipients present in orally administered FDA-approved drug products on the intestinal efflux transporter, BCRP (ABCG2), which plays a critical role in drug absorption with potential implications on drug safety and efficacy. We determined the interactions of 136 oral mol. excipients with BCRP in isolated membrane vesicles and identified 26 excipients as BCRP inhibitors with IC50 values less than 5 \u03bcM using 3H-cholecystokinin octapeptide (3H-CCK8). These BCRP inhibitors belonged to three functional categories of excipients: dyes, surfactants, and flavoring agents. Compared with noninhibitors, BCRP inhibitors had significantly higher mol. weights and SLogP values. The inhibitory effects of excipients identified in membrane vesicles were also evaluated in BCRP-overexpressing HEK293 cells at similar concentrations Only 1 of the 26 inhibitors of BCRP identified in vesicles inhibited BCRP-mediated 3H-oxypurinol uptake by more than 50%, consistent with the notion that BCRP inhibition depends on transmembrane or intracellular availability of the inhibitors. Collectively, the results of this study provide new information on excipient selection during the development of drug products with active pharmaceutical ingredients that are BCRP substrates.<\/p>\n

Compound(25956-17-6)Computed Properties of C18H14N2Na2O8S2<\/a> received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate), if you are interested, you can check out my other related articles.<\/p>\n

Reference:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/A><\/p>\n","protected":false},"excerpt":{"rendered":"

Compound(25956-17-6)Computed Properties of C18H14N2Na2O8S2<\/a> received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate), if you are interested, you can check out my other related articles.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[727,131],"tags":[500],"class_list":["post-9540","post","type-post","status-publish","format-standard","hentry","category-25956-17-6","category-pyrazoles-derivatives","tag-m-w400-500"],"yoast_head":"\nShare an extended knowledge of a compound : 25956-17-6 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zou, Ling; Pottel, Joshua; Khuri, Natalia; Ngo, Huy X.; Ni, Zhanglin; Tsakalozou, Eleftheria; Warren, Mark S.; Huang, Yong; Shoichet, Brian K.; Giacomini, Kathleen M. researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).Computed Properties of C18H14N2Na2O8S2.They published the article \u300aInteractions of Oral Molecular Excipients with Breast Cancer Resistance Protein, BCRP\u300b about this compound( cas:25956-17-6 ) in Molecular Pharmaceutics. 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We'll tell you more about this compound (cas:25956-17-6).\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=9540\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Share an extended knowledge of a compound : 25956-17-6 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zou, Ling; Pottel, Joshua; Khuri, Natalia; Ngo, Huy X.; Ni, Zhanglin; Tsakalozou, Eleftheria; Warren, Mark S.; Huang, Yong; Shoichet, Brian K.; Giacomini, Kathleen M. researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).Computed Properties of C18H14N2Na2O8S2.They published the article \u300aInteractions of Oral Molecular Excipients with Breast Cancer Resistance Protein, BCRP\u300b about this compound( cas:25956-17-6 ) in Molecular Pharmaceutics. 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