{"id":9517,"date":"2022-04-06T09:46:17","date_gmt":"2022-04-06T01:46:17","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=9517"},"modified":"2022-04-06T09:46:17","modified_gmt":"2022-04-06T01:46:17","slug":"a-new-synthetic-route-of-25956-17-6-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=9517","title":{"rendered":"A new synthetic route of 25956-17-6"},"content":{"rendered":"

Zou, Ling; Spanogiannopoulos, Peter; Pieper, Lindsey M.; Chien, Huan-Chieh; Cai, Wenlong; Khu, Natalia; Pottel, Joshua; Vora, Bianca; Ni, Zhanglin; Tsakalozou, Eleftheria; Zhangc, Wenjun; Shoichet, Brian K.; Giacomini, Kathleen M.; Turnbaugh, Peter J. published an article about the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6,SMILESS:O=S(C1=CC=C2C(\/N=N\/C3=CC(C)=C(S(=O)([O-])=O)C=C3OC)=C(O)C=CC2=C1)([O-])=O.[Na+].[Na+] ).Formula: C18H14N2Na2O8S2<\/a>. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:25956-17-6) through the article.<\/p>\n

Food and drug products contain diverse and abundant smallmol. additives (excipients) with unclear impacts on human physiol., drug safety, and response. Here, we evaluate their potential impact on intestinal drug absorption. By screening 136 unique compounds for inhibition of the key intestinal transporter OATP2B1 we identified and validated 24 potent OATP2B1 inhibitors, characterized by higher mol. weight and hydrophobicity compared to poor or noninhibitors. OATP2B1 inhibitors were also enriched for dyes, including 8 azo (R-N=N-R\u2032) dyes. Pharmacokinetic studies in mice confirmed that FD\u2032C Red Number 40, a common azo dye excipient and a potent inhibitor of OATP2B1, decreased the plasma level of the OATP2B1 substrate fexofenadine, suggesting that FD\u2032C Red Number 40 has the potential to block drug absorption through OATP2B1 inhibition in vivo. However, the gut microbiomes of multiple unrelated healthy individuals as well as diverse human gut bacterial isolates were capable of inactivating the identified azo dye excipients, producing metabolites that no longer inhibit OATP2B1 transport. These results support a beneficial role for the microbiome in limiting the unintended effects of food and drug additives in the intestine and provide a framework for the data-driven selection of excipients. Furthermore, the ubiquity and genetic diversity of gut bacterial azoreductases coupled to experiments in conventionally raised and gnotobiotic mice suggest that variations in gut microbial community structure may be less important to consider relative to the high concentrations of azo dyes in food products, which have the potential to saturate gut bacterial enzymic activity.<\/p>\n

In some applications, this compound(25956-17-6)Formula: C18H14N2Na2O8S2<\/a> is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.<\/p>\n

Reference:
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/A><\/p>\n","protected":false},"excerpt":{"rendered":"

In some applications, this compound(25956-17-6)Formula: C18H14N2Na2O8S2<\/a> is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[727,131],"tags":[500],"class_list":["post-9517","post","type-post","status-publish","format-standard","hentry","category-25956-17-6","category-pyrazoles-derivatives","tag-m-w400-500"],"yoast_head":"\nA new synthetic route of 25956-17-6 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Zou, Ling; Spanogiannopoulos, Peter; Pieper, Lindsey M.; Chien, Huan-Chieh; Cai, Wenlong; Khu, Natalia; Pottel, Joshua; Vora, Bianca; Ni, Zhanglin; Tsakalozou, Eleftheria; Zhangc, Wenjun; Shoichet, Brian K.; Giacomini, Kathleen M.; Turnbaugh, Peter J. published an article about the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6,SMILESS:O=S(C1=CC=C2C(\/N=N\/C3=CC(C)=C(S(=O)([O-])=O)C=C3OC)=C(O)C=CC2=C1)([O-])=O.[Na+].[Na+] ).Formula: C18H14N2Na2O8S2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:25956-17-6) through the article.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=9517\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new synthetic route of 25956-17-6 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Zou, Ling; Spanogiannopoulos, Peter; Pieper, Lindsey M.; Chien, Huan-Chieh; Cai, Wenlong; Khu, Natalia; Pottel, Joshua; Vora, Bianca; Ni, Zhanglin; Tsakalozou, Eleftheria; Zhangc, Wenjun; Shoichet, Brian K.; Giacomini, Kathleen M.; Turnbaugh, Peter J. published an article about the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6,SMILESS:O=S(C1=CC=C2C(\/N=N\/C3=CC(C)=C(S(=O)([O-])=O)C=C3OC)=C(O)C=CC2=C1)([O-])=O.[Na+].[Na+] ).Formula: C18H14N2Na2O8S2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. 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