{"id":946,"date":"2020-11-04T10:51:24","date_gmt":"2020-11-04T02:51:24","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=946"},"modified":"2020-11-04T10:51:24","modified_gmt":"2020-11-04T02:51:24","slug":"the-important-role-of-3-amino-1h-pyrazole-4-carbonitrile","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=946","title":{"rendered":"The important role of 3-Amino-1H-pyrazole-4-carbonitrile"},"content":{"rendered":"

16617-46-2<\/a>, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below.<\/p>\n

The compound 5-amino-1H-pyrazole-4-carbonitrile 7a (20 g, 185 mmol) It was dissolved in N, N-dimethylformamide (200 mL), cooled to 0 C, and N-bromosuccinimide (34 g, 190 mmol) was added in portions, and the mixture was warmed to room temperature and stirred for 2 hours.The reaction solution was poured into a sodium sulfite solution, and extracted with ethyl acetate (200 mL \u00a1\u00c1 3). The organic phases were combined and dried over anhydrous sodium sulfate, filtered to remove the drying agent, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloro Methane \/ methanol = 20\/1) to give the target product 5-amino-3-bromo-1H-pyrazole-4-carbonitrile 7b (32 g, yellow solid), yield: 93%.<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[193,131],"tags":[126],"class_list":["post-946","post","type-post","status-publish","format-standard","hentry","category-16617-46-2","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of 3-Amino-1H-pyrazole-4-carbonitrile<\/title>\n<meta name=\"description\" content=\"16617-46-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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