{"id":945,"date":"2020-11-04T10:51:24","date_gmt":"2020-11-04T02:51:24","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=945"},"modified":"2020-11-04T10:51:24","modified_gmt":"2020-11-04T02:51:24","slug":"analyzing-the-synthesis-route-of-3-nitro-1h-pyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=945","title":{"rendered":"Analyzing the synthesis route of 3-Nitro-1H-pyrazole"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 26621-44-3, name is 3-Nitro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., 26621-44-3<\/a><\/p>\n

To a mixture of 3-nitro-iH-pyrazole (30 g, 265.31 mmol, 1 eq) in DMF (300 mL) was added NaH (11.14 g, 278.58 mmol, 60% purity in mineral oil, 1.05 eq) in portions at o C. Then the reaction mixture was stirred at o C for 0.5 hour. 2-Bromopropane (39.16 g, 318.37 mmol, 1.2 eq) was added and the resulting mixture was warmed to 25 C for 12 hours. The reaction mixture was quenched with water (500 mL) and extracted with EtOAc (3 x 300 mL). The combined organic layers were washed with brine (100 mL), dried over anhydrous Na2S04, filtered and concentrated in vacuo. The residue was purified by chromatography (Si02, petroleum ether: ethyl acetate, 50:1 to 2:1) to give the title compound (29.2 g, 71 %) as a yellow oil. (0810) NMR (400 MHz, CDCI3) d 749 (d, 1 H), 6.90 (d, 1 H), 4-634-56 (m, 1 H) and 1.58 (d, 6 H).<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[163,131],"tags":[126],"class_list":["post-945","post","type-post","status-publish","format-standard","hentry","category-26621-44-3","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nAnalyzing the synthesis route of 3-Nitro-1H-pyrazole<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 26621-44-3, name is 3-Nitro-1H-pyrazole, This compound has unique chemical properties. 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