{"id":9448,"date":"2022-03-31T12:08:26","date_gmt":"2022-03-31T04:08:26","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=9448"},"modified":"2022-03-31T12:08:26","modified_gmt":"2022-03-31T04:08:26","slug":"share-an-extended-knowledge-of-a-compound-17190-29-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=9448","title":{"rendered":"Share an extended knowledge of a compound : 17190-29-3"},"content":{"rendered":"<p>Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Easy direct stereo- and regioselective formation of \u03b2-hydroxy nitriles by reaction of 1,2-epoxides with potassium cyanide in the presence of metal salts.<a href=\"https:\/\/www.ambeed.com\/products\/17190-29-3.html\">Recommanded Product: 3-Hydroxy-3-phenylpropanenitrile<\/a>.<\/p>\n<p>The metal salt-catalyzed ring opening of epoxides with KCN in MeCN gave regioselectively and stereoselectively \u03b2-hydroxy nitriles. The ring opening reaction is regioselective with attack of the nucleophile only on the sterically less hindered carbon. Treatment of (\u00b1)-1-hexyloxirane with KCN\/LiCLO4 in MeCN gave 95% C5H11CH(OH)CH2CH2CN (97.0% attack at the \u03b2-carbon and 1.8% attack at the \u03b1-carbon). The ring opening reaction is anti-stereoselective, whereby only the trans isomer of the \u03b2-hydroxy nitriles were formed. Ring opening of (+)-1,2-epoxycyclohexane gave 96% trans-3-hydroxy-1-cyclohexanecarbonitrile. With styrene oxide attack of the nucleophile occurred also on the more substituted benzylic carbon.<\/p>\n<p>From this literature\u300aEasy direct stereo- and regioselective formation of \u03b2-hydroxy nitriles by reaction of 1,2-epoxides with potassium cyanide in the presence of metal salts\u300b,we know some information about this compound(17190-29-3)<a href=\"https:\/\/www.ambeed.com\/products\/17190-29-3.html\">Recommanded Product: 3-Hydroxy-3-phenylpropanenitrile<\/a>, but this is not all information, there are many literatures related to this compound(17190-29-3).<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/A><\/p>\n","protected":false},"excerpt":{"rendered":"<p>From this literature\u300aEasy direct stereo- and regioselective formation of \u03b2-hydroxy nitriles by reaction of 1,2-epoxides with potassium cyanide in the presence of metal salts\u300b,we know some information about this compound(17190-29-3)<a href=\"https:\/\/www.ambeed.com\/products\/17190-29-3.html\">Recommanded Product: 3-Hydroxy-3-phenylpropanenitrile<\/a>, but this is not all information, there are many literatures related to this compound(17190-29-3).<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[723,131],"tags":[126],"class_list":["post-9448","post","type-post","status-publish","format-standard","hentry","category-17190-29-3","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Share an extended knowledge of a compound : 17190-29-3 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Easy direct stereo- and regioselective formation of \u03b2-hydroxy nitriles by reaction of 1,2-epoxides with potassium cyanide in the presence of metal salts.Recommanded Product: 3-Hydroxy-3-phenylpropanenitrile.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=9448\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Share an extended knowledge of a compound : 17190-29-3 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Easy direct stereo- and regioselective formation of \u03b2-hydroxy nitriles by reaction of 1,2-epoxides with potassium cyanide in the presence of metal salts.Recommanded Product: 3-Hydroxy-3-phenylpropanenitrile.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=9448\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2022-03-31T04:08:26+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9448\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9448\",\"name\":\"Share an extended knowledge of a compound : 17190-29-3 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2022-03-31T04:08:26+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Easy direct stereo- and regioselective formation of \u03b2-hydroxy nitriles by reaction of 1,2-epoxides with potassium cyanide in the presence of metal salts.Recommanded Product: 3-Hydroxy-3-phenylpropanenitrile.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9448#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=9448\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=9448#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Share an extended knowledge of a compound : 17190-29-3\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Share an extended knowledge of a compound : 17190-29-3 | pyrazoles-derivatives","description":"Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Easy direct stereo- and regioselective formation of \u03b2-hydroxy nitriles by reaction of 1,2-epoxides with potassium cyanide in the presence of metal salts.Recommanded Product: 3-Hydroxy-3-phenylpropanenitrile.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=9448","og_locale":"en_US","og_type":"article","og_title":"Share an extended knowledge of a compound : 17190-29-3 | pyrazoles-derivatives","og_description":"Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Easy direct stereo- and regioselective formation of \u03b2-hydroxy nitriles by reaction of 1,2-epoxides with potassium cyanide in the presence of metal salts.Recommanded Product: 3-Hydroxy-3-phenylpropanenitrile.","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=9448","og_site_name":"pyrazoles-derivatives","article_published_time":"2022-03-31T04:08:26+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=9448","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=9448","name":"Share an extended knowledge of a compound : 17190-29-3 | pyrazoles-derivatives","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2022-03-31T04:08:26+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Easy direct stereo- and regioselective formation of \u03b2-hydroxy nitriles by reaction of 1,2-epoxides with potassium cyanide in the presence of metal salts.Recommanded Product: 3-Hydroxy-3-phenylpropanenitrile.","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=9448#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=9448"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=9448#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Share an extended knowledge of a compound : 17190-29-3"}]},{"@type":"WebSite","@id":"https:\/\/www.pyrazoles-derivatives.com\/#website","url":"https:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1","name":"Jessica.F","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/","url":"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g","contentUrl":"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g","caption":"Jessica.F"}}]}},"_links":{"self":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts\/9448","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9448"}],"version-history":[{"count":0,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts\/9448\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9448"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9448"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9448"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}