{"id":9424,"date":"2022-03-30T09:50:14","date_gmt":"2022-03-30T01:50:14","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=9424"},"modified":"2022-03-30T09:50:14","modified_gmt":"2022-03-30T01:50:14","slug":"chemical-research-in-23077-42-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=9424","title":{"rendered":"Chemical Research in 23077-42-1"},"content":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/23077-42-1.html\">Name: 4-Fluoro-1H-indole-3-carboxylic acid<\/a>. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 4-Fluoro-1H-indole-3-carboxylic acid, is researched, Molecular C9H6FNO2, CAS is 23077-42-1, about Improved synthesis of some fluoroindoles. Author is Kalir, Asher; Balderman, D..<\/p>\n<p>2,5-F2-C6-H3NO2 (109 g.) was treated with 155 g. NCCH2CO2Et and 31.6 g. Na in 1000 ml. EtOH for 2 hrs. to give 26% 4-fluoroanthro-xanonitrile, m. 70-1\u00b0. 2,4-(O2N)FC6H3Me (155 g.) was refluxed 14 hrs. with 196 g. N-bromosuccinimide in 600 ml. CCl4 and 2 g. benzoyl peroxide and treated directly with pyridine to give 198 g. I (X = 4-F), m. 201-2\u00b0, and 37 g. 2,4-(O2N)FC6H3-CHBr2, m. 63-4\u00b0. I (X = 5-F and 6-F), m. 189-90\u00b0, and 202-4\u00b0, resp., were similarly obtained in 64 and 71% yield. I (X = 4-F) was treated with 150 g. p-ONC6H4NMe2.HCl in 1 l. EtOH and 720 ml. 2.5N NaOH at <5\u00b0 for 1 hr., and then treated with 1.5 l. 6N H2SO4 to give 86 g. 2-O2N X C6H3CHO (II) (where X = 4-F), m. 32-3\u00b0, via III (X = 4-F), m. 165-6\u00b0. The following compounds were similarly prepared (X, % yield II, m.p. II, % yield III, and m.p. III given): 5-F, 86, 94-5\u00b0, 92, 155-6\u00b0; 6-F, 95, 62-3\u00b0, 96, 151-2\u00b0. II (X = 6-F) was treated with MeNO2 to give 76% 2,4-F(O2N)C6H3CH:CHNO2, m. 84\u00b0, which was catalytically reduced to 34-63% 4-fluoroindole, m. 29-30\u00b0, accompanied by IV, m. 200\u00b0 (decomposition). The method of K. and S. Szara (1963) was used to prepare V (R, % yield, and m.p. given): CHO, 73, 190-1\u00b0; CH:CMeNO2, 81, 191-2\u00b0; CH2CHMeNH2, 64, 103-5\u00b0 (HCl salt m. 240-1\u00b0, picrate m. 222-3\u00b0). 6-Fluoro-3-(2-nitrovinyl)indole, m. 190-2\u00b0, and 6-fluorotryptamine m. 83-4\u00b0, were similarly prepared in 68 and 51% yield, resp. V (R = CHO) (3.5 g.) was treated with 6 g. KMnO4 in 120 ml. Me2CO at <40\u00b0 to give 47% V (R = CO2H), m. 273\u00b0 (decomposition). 5-Fluoro-3-indolecarboxylic acid, m. 234-6\u00b0 (decomposition), and 6-fluoro-3-indolecarboxylic acid, m. 242-4\u00b0 (decomposition), were similarly prepared in 54 and 48% yield, resp. V (R = CH2CHMeNH2) was less active than the 5-fluoro derivative, but more active than the 6-fluoro derivative in the activity cage test on mice.\n\nIf you want to learn more about this compound(4-Fluoro-1H-indole-3-carboxylic acid)<a href=\"https:\/\/www.ambeed.com\/products\/23077-42-1.html\">Name: 4-Fluoro-1H-indole-3-carboxylic acid<\/a>, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(23077-42-1).<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/A><\/p>\n","protected":false},"excerpt":{"rendered":"<p>If you want to learn more about this compound(4-Fluoro-1H-indole-3-carboxylic acid)<a href=\"https:\/\/www.ambeed.com\/products\/23077-42-1.html\">Name: 4-Fluoro-1H-indole-3-carboxylic acid<\/a>, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(23077-42-1).<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[728,131],"tags":[126],"class_list":["post-9424","post","type-post","status-publish","format-standard","hentry","category-23077-42-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Chemical Research in 23077-42-1 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Name: 4-Fluoro-1H-indole-3-carboxylic acid. 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