{"id":942,"date":"2020-11-04T10:51:24","date_gmt":"2020-11-04T02:51:24","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=942"},"modified":"2020-11-04T10:51:24","modified_gmt":"2020-11-04T02:51:24","slug":"analyzing-the-synthesis-route-of-1-methyl-1h-pyrazol-5-amine","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=942","title":{"rendered":"Analyzing the synthesis route of 1-Methyl-1H-pyrazol-5-amine"},"content":{"rendered":"

1192-21-8<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1192-21-8 as follows.<\/p>\n

Sparge a solution of 2-(2-chloro-4-pyridyi)-5-2-cyclopropoxy)ethyl]-6,6- dimethyi-thieno[2,3-c]pyrrol-4-one (13.9 g, 121 mmol), i-methyi-5-aminopyrazole (ii g, 113 rnrnoi), and sodium tert-butoxide (6.5 g, 68 mrnol) in toluene (150 mL) with nitrogen for 15 minutes. Treat the resulting mixture with (R)- I -[(Sp)-2- (dicyciohexyiphosphino)ferrocenyiiethyldi-tert-hutylphosphine (200 mg, 0.36 mmol) andbis(tri-o-toiyiphosphine)paliadium(0) (250 mg, 0.35 mmoi), Heat the reaction mixture to reflux for one hour. Cool the reaction to room temperature and dilute with EtOAc (500 mL), Wash the organic solution with water (300 mL), Separate and concentrate the organic phase under reduced pressure, Dissolve the residue inDCM (150 mL) and treat the solution with SILIAMETS Thiol (40 g, I .28 mrnol\/g, 40-63 micron) and stir the mixture for four hours, Filter to remove the solid and concentrate the filtrate under reduced pressure to give the title compound I LI g (86%). MS (ink): 424 (M+i).<\/p>\n

According to the analysis of related databases, 1-Methyl-1H-pyrazol-5-amine, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 1-Methyl-1H-pyrazol-5-amine, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[191,131],"tags":[145],"class_list":["post-942","post","type-post","status-publish","format-standard","hentry","category-1192-21-8","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nAnalyzing the synthesis route of 1-Methyl-1H-pyrazol-5-amine<\/title>\n<meta name=\"description\" content=\"1192-21-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1192-21-8 as follows.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=942\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Analyzing the synthesis route of 1-Methyl-1H-pyrazol-5-amine\" \/>\n<meta property=\"og:description\" content=\"1192-21-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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