{"id":940,"date":"2020-11-04T10:51:24","date_gmt":"2020-11-04T02:51:24","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=940"},"modified":"2020-11-04T10:51:24","modified_gmt":"2020-11-04T02:51:24","slug":"sources-of-common-compounds-402-61-9","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=940","title":{"rendered":"Sources of common compounds: 402-61-9"},"content":{"rendered":"

402-61-9<\/a>, Name is 5-Methyl-1H-pyrazole-3-carboxylic acid, 402-61-9, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.<\/p>\n

To a solution of 5-methyl-1H-pyrazole-3-carboxylic acid (45 g) in MeOH (450 mL) is added dropwise thionylchloride (58 mL). After addition the mixture is stirred for 16 h at room temperature. The mixture is concentrated in vacuo. The residue is dissolved in EtOAC, washed successively with saturated aqueous NaHCO3 and brine. After drying (MgSO4) the mixture is concentrated in vacuo to give the title compound. LC (Method 1): tR=0.64 min; Mass spectrum (ESI+): m\/z=141 [M+H]+.<\/p>\n

Statistics shows that 5-Methyl-1H-pyrazole-3-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 402-61-9.<\/p>\n","protected":false},"excerpt":{"rendered":"

Statistics shows that 5-Methyl-1H-pyrazole-3-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 402-61-9.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[159,131],"tags":[126],"class_list":["post-940","post","type-post","status-publish","format-standard","hentry","category-402-61-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSources of common compounds: 402-61-9<\/title>\n<meta name=\"description\" content=\"402-61-9, Name is 5-Methyl-1H-pyrazole-3-carboxylic acid, 402-61-9, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. 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