{"id":9396,"date":"2022-02-25T08:30:13","date_gmt":"2022-02-25T00:30:13","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=9396"},"modified":"2022-02-25T08:30:13","modified_gmt":"2022-02-25T00:30:13","slug":"a-new-application-about-c4h4n2o-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=9396","title":{"rendered":"A new application about C4H4N2O"},"content":{"rendered":"

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 35344-95-7, Name is 1H-Pyrazole-4-carbaldehyde, formurla is C4H4N2O. In a document, author is Wang, Guangcheng, introducing its new discovery. SDS of cas: 35344-95-7<\/a>.<\/p>\n

A new series of pyrazole-naphthalene derivatives (5a-5q) have been synthesized and evaluated for their anticancer activity against human breast cancer cell lines (MCF-7). Most of newly synthesized compounds (except 5i, 5m, and 5p) exhibited potent antiproliferative activity in the range of IC50 = 2.78 +\/- 0.24 mu M – 9.13 +\/- 0.47 mu M. Among them, compound 5j (IC50 = 2.78 +\/- 0.24 mu M), bearing ethoxy at the 4-position of the phenyl ring, was found to be the most active compound in this series of compounds, with five folds more active than the standard drug cisplatin (IC50 = 15.24 +\/- 1.27 mu M). In addition, compound 5j and colchicine showed the same ability to inhibit tubulin polymerization with the IC50 values of 4.6 mu M and 6.7 mu M, respectively. Cellular mechanism studies elucidated that compound 5j arrested the cell cycle at G2\/M phase and induced apoptosis. Furthermore, molecular docking analysis revealed that compound 5j formed stable interactions in the colchicine-binding site of tubulin.<\/p>\n

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 35344-95-7 help many people in the next few years. SDS of cas: 35344-95-7<\/a>.<\/p>\n

Reference:
Pyrazole – Wikipedia<\/a>,
,Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 35344-95-7 help many people in the next few years. SDS of cas: 35344-95-7<\/a>.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[154,131],"tags":[145],"class_list":["post-9396","post","type-post","status-publish","format-standard","hentry","category-35344-95-7","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nA new application about<\/title>\n<meta name=\"description\" content=\"One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 35344-95-7, Name is 1H-Pyrazole-4-carbaldehyde, formurla is C4H4N2O. 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