{"id":9275,"date":"2022-02-15T07:00:56","date_gmt":"2022-02-14T23:00:56","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=9275"},"modified":"2022-02-15T07:00:56","modified_gmt":"2022-02-14T23:00:56","slug":"some-scientific-research-about-c5h8n2-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=9275","title":{"rendered":"Some scientific research about C5H8N2"},"content":{"rendered":"

Computed Properties of C5H8N2<\/a>. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Potential 2,4-dimethyl-1H-pyrrole-3-carboxamide bearing benzimidazole template: Design, synthesis, in vitro anticancer and in silico ADME study published in 2020.0, Reprint Addresses Jagtap, SV (corresponding author), Savitribai Phule Pune Univ, Baburaoji Gholap Coll, Dept Chem, Pune 411017, Maharashtra, India.. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole.<\/p>\n

A new series of 2,4-dimethyl-1H-pyrrole-3-carboxamide derivatives bearing benzimidazole moiety was synthesized through a molecular hybridization approach and evaluated for in vitro anticancer activity by NCI-60 on leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate and breast cancer cell lines at a single dose (10 mu M). Among all the synthesized conjugates, some derivatives showed more or less good activity even at such a small dose, while, compound 5-(1H-benzo[d]imidazol-2-yl) N (1-cyclohexylethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (80 displayed significant antiproliferative activity specifically against MDA-MB human cancer cell lines. Compound 8f showed promising activity against MDA-MB-435 cell line of melanoma (Growth inhibition: 62.46%) and MDA-MB-468 cell line of breast (Growth inhibition: 40.24%). Computational ADME study qualified its significant physicochemical, pharmacokinetic and drug-likeness properties with good predicted oral bioavailability. Thus this new hybrid molecules would be useful for further anticancer drug development.<\/p>\n

Computed Properties of C5H8N2<\/a>. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Basal, NK; Sonawane, RB; Jagtap, SV or concate me.<\/p>\n

Reference:
Pyrazole – Wikipedia<\/a>,
,Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Computed Properties of C5H8N2<\/a>. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Basal, NK; Sonawane, RB; Jagtap, SV or concate me.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[249,131],"tags":[145],"class_list":["post-9275","post","type-post","status-publish","format-standard","hentry","category-67-51-6","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nSome scientific research about C5H8N2 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Computed Properties of C5H8N2. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Potential 2,4-dimethyl-1H-pyrrole-3-carboxamide bearing benzimidazole template: Design, synthesis, in vitro anticancer and in silico ADME study published in 2020.0, Reprint Addresses Jagtap, SV (corresponding author), Savitribai Phule Pune Univ, Baburaoji Gholap Coll, Dept Chem, Pune 411017, Maharashtra, India.. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=9275\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Some scientific research about C5H8N2 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Computed Properties of C5H8N2. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Potential 2,4-dimethyl-1H-pyrrole-3-carboxamide bearing benzimidazole template: Design, synthesis, in vitro anticancer and in silico ADME study published in 2020.0, Reprint Addresses Jagtap, SV (corresponding author), Savitribai Phule Pune Univ, Baburaoji Gholap Coll, Dept Chem, Pune 411017, Maharashtra, India.. The CAS is 67-51-6. 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