{"id":914,"date":"2020-10-30T10:37:01","date_gmt":"2020-10-30T02:37:01","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=914"},"modified":"2020-10-30T10:37:01","modified_gmt":"2020-10-30T02:37:01","slug":"discovery-of-14-dimethylpyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=914","title":{"rendered":"Discovery of 1,4-Dimethylpyrazole"},"content":{"rendered":"

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1072-68-0 as follows. 1072-68-0<\/a><\/p>\n

To a solution of 1,4-dimethyl-1H-pyrazole (52 g, 541 mmol) in anhydrous THF (1.0 L) was added dropwise n-BuLi (0.22 L, 2.5 M, 550 mmol) at -78 C with stirring over 2 h. Then, a solution of (RS)-4 (110 g, 396 mmol) in anhydrous THF (1.0 L) was added dropwise to the above solution over 1 h at the same temperature. The resulting mixture was stirred at -78 C for 1.5 h. TLC (PE-EtOAc, 1:2) showed (RS)-4 was completely consumed. The mixture was poured into sat. aq NH4Cl (1 L) and extracted with EtOAc (3 \u00a1\u00c1 0.8 L). The combined organic extracts were washed with brine (1 L), dried (Na2SO4), and concentrated to give the crude product. Purification by column chromatography on silica gel (PE-EtOAc, 20:1 ? 5:1) gave 8i as a yellow oil, and 7i as a yellow solid when the column was continuously eluted with PE-EtOAc(5:1 ? 2:1).<\/p>\n

According to the analysis of related databases, 1072-68-0, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 1072-68-0, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[179,131],"tags":[145],"class_list":["post-914","post","type-post","status-publish","format-standard","hentry","category-1072-68-0","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nDiscovery of 1,4-Dimethylpyrazole<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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