{"id":913,"date":"2020-10-30T10:37:01","date_gmt":"2020-10-30T02:37:01","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=913"},"modified":"2020-10-30T10:37:01","modified_gmt":"2020-10-30T02:37:01","slug":"simple-exploration-of-6076-12-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=913","title":{"rendered":"Simple exploration of 6076-12-6"},"content":{"rendered":"

These common heterocyclic compound, 6076-12-6, name is Ethyl 4-methyl-1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 6076-12-6<\/a><\/p>\n

Ethyl 4-methyl-1 H-pyrazole-3-carboxylate (Intermediate 33) (1.0 g, 6.49 mmol) was dissolved in DMF : H20 (9.0 mL : 1.0 mL) and K20O3(3.58 g, 25.9 mmol) and sodium 2-chloro-2,2-difluoroacetate (Intermediate 35) (3.94 g, 25.9 mmol) were added at 0 C and then the mixture was heated at 130 C for 20 min. The reaction mixture was cooled to RT and ice-cold water was added. The aqueous layer was extracted with EtOAc (3 x 50 mL) and the combined organic layer was washed with brine solution, dried over Na2S04, filtered and concentrated. The residue was purified by column chromatography (Normal-Phase 60-120 mesh silica gel, 25 % EtOAc in hexanes) to give ethyl 1- (difluoromethyl)-4-methyl-1 \/-\/-pyrazole-3-carboxylate (325 mg, 25 %) as a solid.LCMS (System 3, Method D): m\/z 205 (M+H)+(ESI +ve), at 3.77 min, 202 nm.<\/p>\n

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6076-12-6.<\/p>\n","protected":false},"excerpt":{"rendered":"

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6076-12-6.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[177,131],"tags":[126],"class_list":["post-913","post","type-post","status-publish","format-standard","hentry","category-6076-12-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSimple exploration of 6076-12-6<\/title>\n<meta name=\"description\" content=\"These common heterocyclic compound, 6076-12-6, name is Ethyl 4-methyl-1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 6076-12-6\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=913\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Simple exploration of 6076-12-6\" \/>\n<meta property=\"og:description\" content=\"These common heterocyclic compound, 6076-12-6, name is Ethyl 4-methyl-1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 6076-12-6\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=913\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2020-10-30T02:37:01+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=913\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=913\",\"name\":\"Simple exploration of 6076-12-6\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2020-10-30T02:37:01+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"These common heterocyclic compound, 6076-12-6, name is Ethyl 4-methyl-1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 6076-12-6\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=913#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=913\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=913#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Simple exploration of 6076-12-6\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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