{"id":9073,"date":"2022-01-29T03:27:05","date_gmt":"2022-01-28T19:27:05","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=9073"},"modified":"2022-01-29T03:27:05","modified_gmt":"2022-01-28T19:27:05","slug":"lets-talk-about-compound-67-51-6-9","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=9073","title":{"rendered":"Let`s talk about compound :67-51-6"},"content":{"rendered":"

Formula: C5H8N2<\/a>. In 2020.0 BIOORG CHEM published article about NATIONAL-CANCER-INSTITUTE; TYROSINE KINASE; DRUG DISCOVERY; HYBRID in [Basal, Nishant K.; Sonawane, Rahul B.; Jagtap, Sangeeta, V] Savitribai Phule Pune Univ, Baburaoji Gholap Coll, Dept Chem, Pune 411017, Maharashtra, India in 2020.0, Cited 26.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6.<\/p>\n

A new series of 2,4-dimethyl-1H-pyrrole-3-carboxamide derivatives bearing benzimidazole moiety was synthesized through a molecular hybridization approach and evaluated for in vitro anticancer activity by NCI-60 on leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate and breast cancer cell lines at a single dose (10 mu M). Among all the synthesized conjugates, some derivatives showed more or less good activity even at such a small dose, while, compound 5-(1H-benzo[d]imidazol-2-yl) N (1-cyclohexylethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (80 displayed significant antiproliferative activity specifically against MDA-MB human cancer cell lines. Compound 8f showed promising activity against MDA-MB-435 cell line of melanoma (Growth inhibition: 62.46%) and MDA-MB-468 cell line of breast (Growth inhibition: 40.24%). Computational ADME study qualified its significant physicochemical, pharmacokinetic and drug-likeness properties with good predicted oral bioavailability. Thus this new hybrid molecules would be useful for further anticancer drug development.<\/p>\n

Formula: C5H8N2<\/a>. Bye, fridends, I hope you can learn more about C5H8N2, If you have any questions, you can browse other blog as well. See you lster.<\/p>\n

Reference:
Pyrazole – Wikipedia<\/a>,
,Pyrazoles – an overview | ScienceDirect Topics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Formula: C5H8N2<\/a>. Bye, fridends, I hope you can learn more about C5H8N2, If you have any questions, you can browse other blog as well. See you lster.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[249,131],"tags":[145],"class_list":["post-9073","post","type-post","status-publish","format-standard","hentry","category-67-51-6","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nLet`s talk about compound :67-51-6 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Formula: C5H8N2. In 2020.0 BIOORG CHEM published article about NATIONAL-CANCER-INSTITUTE; TYROSINE KINASE; DRUG DISCOVERY; HYBRID in [Basal, Nishant K.; Sonawane, Rahul B.; Jagtap, Sangeeta, V] Savitribai Phule Pune Univ, Baburaoji Gholap Coll, Dept Chem, Pune 411017, Maharashtra, India in 2020.0, Cited 26.0. The Name is 3,5-Dimethyl-1H-pyrazole. 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