{"id":876,"date":"2020-10-27T13:32:45","date_gmt":"2020-10-27T05:32:45","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=876"},"modified":"2020-10-27T13:32:45","modified_gmt":"2020-10-27T05:32:45","slug":"the-important-role-of-ethyl-4-methyl-1h-pyrazole-3-carboxylate","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=876","title":{"rendered":"The important role of Ethyl 4-methyl-1H-pyrazole-3-carboxylate"},"content":{"rendered":"

6076-12-6<\/a>, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6076-12-6, name is Ethyl 4-methyl-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below.<\/p>\n

Compound 258.1. Ethyl 5-iodo-4-methyl-lH-pyrazole-3-carboxylate. Into a 250- mL round-bottom flask, was placed a solution of ethyl 4-methyl-lH-pyrazole-3-carboxylate (600 mg, 3.89 mmol) in N,N-dimethylformamide (20 mL). MS (2.2 g, 9.78 mmol) was added and the resulting mixture was stirred for 6 h at 50 C, then quenched with water (10 mL). The mixture was extracted with ethyl acetate (3 x 40 mL) and the combined organic extracts were washed with aqueous a2S203 (sat., 2 x 30 mL) and brine (2 x 20 mL), dried ( a2S04), filtered and concentrated under reduced pressure. The residue was purified by a silica gel chromatography with ethyl acetate\/petroleum ether (1 : 10) as eluent to obtain the title compound as a white solid (800 mg, 73%).<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[177,131],"tags":[126],"class_list":["post-876","post","type-post","status-publish","format-standard","hentry","category-6076-12-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of Ethyl 4-methyl-1H-pyrazole-3-carboxylate<\/title>\n<meta name=\"description\" content=\"6076-12-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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