{"id":868,"date":"2020-10-27T13:32:45","date_gmt":"2020-10-27T05:32:45","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=868"},"modified":"2020-10-27T13:32:45","modified_gmt":"2020-10-27T05:32:45","slug":"analyzing-the-synthesis-route-of-139755-99-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=868","title":{"rendered":"Analyzing the synthesis route of 139755-99-0"},"content":{"rendered":"

A common compound: 139755-99-0, name is 1-Methyl-3-propyl-1H-pyrazole-5-carboxylic acid, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 139755-99-0<\/a><\/p>\n

Step 5 2-Methyl-4-nitro-5-propyl-2H-pyrazole-3-carboxylic acid: A solution of 2-methyl-5-propyl-2H-pyrazole-3-carboxylic acid (22 g, 131 mmol) in concentrated sulfuric acid (98%, 85 mL) was heated to 50 C. and treated with a mixture of fuming nitric acid (95%, 7.7 mL) and concentrated sulfuric acid (98%, 18 mL), while keeping the reaction temperature between 50 and 55 C. The reaction mixture was kept for 8 hours at 50 C., cooled to ambient temperature, and slowly added to cold water (600 mL, 4 C.), keeping the temperature below 25 C. The precipitate was collected by filtration, and dried below 80 C. to give the title compound as a white solid (25 g, 90%). 1H NMR (300 MHz, CDCl3) delta 4.25 (s, 3H), 2.92 (t, 2H, J=7.5 Hz), 1.77-1.70 (m, 2H), 1.03 (t, 3H, J=7.2 Hz); LC-MS: m\/z=214 (M+H)+<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 139755-99-0, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 139755-99-0, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[165,131],"tags":[126],"class_list":["post-868","post","type-post","status-publish","format-standard","hentry","category-139755-99-0","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nAnalyzing the synthesis route of 139755-99-0<\/title>\n<meta name=\"description\" content=\"A common compound: 139755-99-0, name is 1-Methyl-3-propyl-1H-pyrazole-5-carboxylic acid, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 139755-99-0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=868\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Analyzing the synthesis route of 139755-99-0\" \/>\n<meta property=\"og:description\" content=\"A common compound: 139755-99-0, name is 1-Methyl-3-propyl-1H-pyrazole-5-carboxylic acid, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. 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