{"id":860,"date":"2020-10-23T12:57:11","date_gmt":"2020-10-23T04:57:11","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=860"},"modified":"2020-10-23T12:57:11","modified_gmt":"2020-10-23T04:57:11","slug":"the-important-role-of-4-amino-1-methyl-3-n-propyl-1h-pyrazole-5-carboxamide","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=860","title":{"rendered":"The important role of 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide"},"content":{"rendered":"

139756-02-8<\/a>, Adding a certain compound to certain chemical reactions, such as: 139756-02-8, name is 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 139756-02-8.<\/p>\n

Synthesis of Bm; Step 7: 4-amino-i-methyl-3-propyl-iH-pyrazole-5-carboxamide (1 eq) and 2-chlorobenzaldehyde (1.1 eq) were suspended in ethanol 5 ml and the mixture heated at 65 C for 2 hours after conformation of forming of imine by TLC. AddedCuC12 (3 eq) and the reaction mixture heated at 70 C under 02 for 2 hours. After completion of the reaction, the ethanol was removed under vacuum. Then workup with ethyl acetate and water. Separate the organic layer and Water layer re-extracted with 2x25m1 ethyl acetate. The combined organic layers are washed with brine solution, concentrated under vacuum. The residue was purified by column chromatography onsilica the desired product Bm as a white solid; yield 88%. ?H NMR (200 MHz CDC13) oe12.06 (s 1H ),8.0i (M, 1H), 7.45 (m, 1H), 7.32 (td, J= 7.8, 1.5 Hz, 1H), 7.21 (td, J=7.5, 1.4 Hz, 111), 4.05 (s, 3H), 3.03 (t, J= 7.4 Hz, 2H), 1.86 (m, 211), 1.06 (t, J- 7.4 Hz,3H). MASS: ESI [M + H] + : 287.12; Elemental anal. calcd. for C15H15FN40 ; C,62.93; H, 5.28; F, 6.64; N, 19.57; 0, 5.59; found C, 62.88; H, 5.31; F, 6.64; N, 19.57;0,5.61.<\/p>\n

According to the analysis of related databases, 139756-02-8, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 139756-02-8, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[157,131],"tags":[126],"class_list":["post-860","post","type-post","status-publish","format-standard","hentry","category-139756-02-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide<\/title>\n<meta name=\"description\" content=\"139756-02-8, Adding a certain compound to certain chemical reactions, such as: 139756-02-8, name is 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 139756-02-8.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=860\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The important role of 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide\" \/>\n<meta property=\"og:description\" content=\"139756-02-8, Adding a certain compound to certain chemical reactions, such as: 139756-02-8, name is 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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