{"id":857,"date":"2020-10-23T12:57:11","date_gmt":"2020-10-23T04:57:11","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=857"},"modified":"2020-10-23T12:57:11","modified_gmt":"2020-10-23T04:57:11","slug":"analyzing-the-synthesis-route-of-18048-64-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=857","title":{"rendered":"Analyzing the synthesis route of 18048-64-1"},"content":{"rendered":"

18048-64-1<\/a>, The chemical industry reduces the impact on the environment during synthesis 18048-64-1, name is 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one, I believe this compound will play a more active role in future production and life.<\/p>\n

A solution of 3′-amino-2′-hydroxy-1 ,1 ‘-biphenyl-3-carboxylic acid hydrochloride salt (1 .31 g 5.725 mmol) in methanol water, obtained as described in Example 4’, was cooled to 0-5 C and a solution of sodium nitrite (0,403 g, 5.840 mmol) in water (2 ml) was added over 15 minutes. The reaction was stirred at 0-10 C for one hour and then it was heated to 20 C. Triethylamine (about 2,5 ml) was added to bring the pH to 8-9 and 1 -(3,4- dimethylphenyl)-3-methyl-1 H-pyrazol-5-ona (1 .16 g, 5,725 mmol) was added in one portion. The mixture was stirred for 2 hours at 20 C maintaining the pH 8-9. Hydrochloric acid (4M, about 4 ml) was added to adjust the pH to 1 .5- 2.0. The precipitate was filtered, washed with water and dried at 40 C to yield 2.492 g (93%).<\/p>\n

The chemical industry reduces the impact on the environment during synthesis 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"excerpt":{"rendered":"

The chemical industry reduces the impact on the environment during synthesis 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[158,131],"tags":[127],"class_list":["post-857","post","type-post","status-publish","format-standard","hentry","category-18048-64-1","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nAnalyzing the synthesis route of 18048-64-1<\/title>\n<meta name=\"description\" content=\"18048-64-1, The chemical industry reduces the impact on the environment during synthesis 18048-64-1, name is 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one, I believe this compound will play a more active role in future production and life.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=857\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Analyzing the synthesis route of 18048-64-1\" \/>\n<meta property=\"og:description\" content=\"18048-64-1, The chemical industry reduces the impact on the environment during synthesis 18048-64-1, name is 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one, I believe this compound will play a more active role in future production and life.\" \/>\n<meta property=\"og:url\" content=\"http:\/\/www.pyrazoles-derivatives.com\/?p=857\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2020-10-23T04:57:11+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=857\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=857\",\"name\":\"Analyzing the synthesis route of 18048-64-1\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2020-10-23T04:57:11+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"18048-64-1, The chemical industry reduces the impact on the environment during synthesis 18048-64-1, name is 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one, I believe this compound will play a more active role in future production and life.\",\"breadcrumb\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=857#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/www.pyrazoles-derivatives.com\/?p=857\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=857#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Analyzing the synthesis route of 18048-64-1\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Analyzing the synthesis route of 18048-64-1","description":"18048-64-1, The chemical industry reduces the impact on the environment during synthesis 18048-64-1, name is 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one, I believe this compound will play a more active role in future production and life.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"http:\/\/www.pyrazoles-derivatives.com\/?p=857","og_locale":"en_US","og_type":"article","og_title":"Analyzing the synthesis route of 18048-64-1","og_description":"18048-64-1, The chemical industry reduces the impact on the environment during synthesis 18048-64-1, name is 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one, I believe this compound will play a more active role in future production and life.","og_url":"http:\/\/www.pyrazoles-derivatives.com\/?p=857","og_site_name":"pyrazoles-derivatives","article_published_time":"2020-10-23T04:57:11+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"http:\/\/www.pyrazoles-derivatives.com\/?p=857","url":"http:\/\/www.pyrazoles-derivatives.com\/?p=857","name":"Analyzing the synthesis route of 18048-64-1","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2020-10-23T04:57:11+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"18048-64-1, The chemical industry reduces the impact on the environment during synthesis 18048-64-1, name is 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one, I believe this compound will play a more active role in future production and life.","breadcrumb":{"@id":"http:\/\/www.pyrazoles-derivatives.com\/?p=857#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["http:\/\/www.pyrazoles-derivatives.com\/?p=857"]}]},{"@type":"BreadcrumbList","@id":"http:\/\/www.pyrazoles-derivatives.com\/?p=857#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Analyzing the synthesis route of 18048-64-1"}]},{"@type":"WebSite","@id":"https:\/\/www.pyrazoles-derivatives.com\/#website","url":"https:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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