{"id":853,"date":"2020-10-22T11:08:34","date_gmt":"2020-10-22T03:08:34","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=853"},"modified":"2020-10-22T11:08:34","modified_gmt":"2020-10-22T03:08:34","slug":"share-a-compound-92525-10-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=853","title":{"rendered":"Share a compound : 92525-10-5"},"content":{"rendered":"

A common compound: 92525-10-5, name is 3-Iodo-1-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 92525-10-5<\/a><\/p>\n

General procedure: To the solution of protected pyrazole 2a-c, 7a, 8a, 12a, 17, 18 or 10a (1 mmol) in 2 mL of dry THFPdCl2(PPh3)2 (14.04 mg, 0.02 mmol) and triethylamine (0.25 g, 2.5 mmol) were added. Reactionmixture was flushed with argon and acetylene (1.2 mmol) were added to the reaction mixturedropwise, following by addition of CuI (1.9 mg, 0.01 mmol) and left to stir at room temperatureovernight. 5 mL of deionized water were added to the reaction mixture, organic layer was separatedand product was extracted with dichloromethane (2 \u00a1\u00c1 5 mL), organic layers were combined andwashed with 5 mL of water, dried with anhydrous Na2SO4 and evaporated under reduced pressure.<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 92525-10-5, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 92525-10-5, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[172,131],"tags":[127],"class_list":["post-853","post","type-post","status-publish","format-standard","hentry","category-92525-10-5","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nShare a compound : 92525-10-5<\/title>\n<meta name=\"description\" content=\"A common compound: 92525-10-5, name is 3-Iodo-1-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 92525-10-5\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=853\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Share a compound : 92525-10-5\" \/>\n<meta property=\"og:description\" content=\"A common compound: 92525-10-5, name is 3-Iodo-1-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. 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