{"id":847,"date":"2020-10-22T11:08:34","date_gmt":"2020-10-22T03:08:34","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=847"},"modified":"2020-10-22T11:08:34","modified_gmt":"2020-10-22T03:08:34","slug":"discovery-of-1h-pyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=847","title":{"rendered":"Discovery of 1H-Pyrazole"},"content":{"rendered":"

A common compound: 288-13-1, name is 1H-Pyrazole, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 288-13-1<\/a><\/p>\n

General procedure: Heterocycle (0.1 mol) was added into a solution of EtONa (8.16 g, 0.24 mol) in EtOH (30 mL) heated to reflux. After the solution was stirred for 30 min, 2-chloroethanol (8 g, 0.2 mol) was added dropwise. The resulting suspension was filtered, and the residue was concentrated by vacuum. The crude product was purified by column chromatography on silica gel to yield the desired product. (Rf = 0.3 (EA\/ CH3OH= 5:1). The esterification procedure was the same as that in the synthesis of N series.<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 288-13-1, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 288-13-1, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[149,131],"tags":[145],"class_list":["post-847","post","type-post","status-publish","format-standard","hentry","category-288-13-1","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nDiscovery of 1H-Pyrazole<\/title>\n<meta name=\"description\" content=\"A common compound: 288-13-1, name is 1H-Pyrazole, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. 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