{"id":839,"date":"2020-10-21T11:15:50","date_gmt":"2020-10-21T03:15:50","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=839"},"modified":"2020-10-21T11:15:50","modified_gmt":"2020-10-21T03:15:50","slug":"extended-knowledge-of-4-fluoro-1h-pyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=839","title":{"rendered":"Extended knowledge of 4-Fluoro-1H-pyrazole"},"content":{"rendered":"

35277-02-2<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35277-02-2 as follows.<\/p>\n

[0129] To a solution of 2-bromo-1-[4-methylphenyl]propan-1-one (IV-2) (commercially available, purity 90%, 1.60 g, 6.34 mmol) in acetonitrile (45 mL) was added successively anhydrous potassium carbonate (1.05 g, 7.61 mmol) and 4-fluoro-1H-pyrazole (546 mg, 6.34 mmol). After stirring at room temperature overnight, the reaction mixture was filtered and concentrated under reduced pressure.Purification of the residue by flash chromatography on silica (cyclohexane\/ethyl acetate, 98\/2 to 70\/3 0) provided 2-(4-fluoro- 1 H-pyrazol- 1 -yl)- 1- [4-methylphenyl]propan- 1-one (v-2) (purity 98%, 1.37 g, 91%). ?H NMR (400 MHz, DMSO-d6) 1.60 (d, 3H), 2.37 (s, 3H), 6.14 (q, 1H), 7.33 (d, 2H), 7.44 (d, 1H), 7.87 (d, 2H), 8.06 (d, 1H).<\/p>\n

According to the analysis of related databases, 4-Fluoro-1H-pyrazole, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 4-Fluoro-1H-pyrazole, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[161,131],"tags":[145],"class_list":["post-839","post","type-post","status-publish","format-standard","hentry","category-35277-02-2","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nExtended knowledge of 4-Fluoro-1H-pyrazole<\/title>\n<meta name=\"description\" content=\"35277-02-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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