{"id":819,"date":"2020-10-19T11:29:01","date_gmt":"2020-10-19T03:29:01","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=819"},"modified":"2020-10-19T11:29:01","modified_gmt":"2020-10-19T03:29:01","slug":"some-scientific-research-about-139756-02-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=819","title":{"rendered":"Some scientific research about 139756-02-8"},"content":{"rendered":"

A common compound: 139756-02-8, name is 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 139756-02-8<\/a><\/p>\n

Synthesis of BJ Step 7. 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide (1 eq) and 4-methoxy-3-nitrobenzaldehyde (1.1 eq) were suspended in ethanol 5 ml and the mixture heated at 75 C for 2 hours after conformation of forming of imine by TLC. Added CuC12 (3 eq) and the reaction mixture heated at 75 C under 02 for 2 hours. Aftercompletion of the reaction, the ethanol was removed under vacuum. Then workup with ethyl acetate and water. Separate the organic layer and Water layer re-extracted with 2×25 ml ethyl acetate. The combined organic layers are washed with brine solution, concentrated under vacuum. The residue was purified by column chromatography on silica the desired product Bf as a brown solid; yield 88%. ?H NMR (400 MHz, DMSO)6: 12.54 (s 1H) 8.61 (s, 1H), 8.37 (d J=8.8 Hz 1H), 7.39 (d, J8.8 Hz 1H), 4.13 (s, 3H),3.84 (s, 3H), 2.78(t J=7.4Hz 2H), 1.76(m 2H), 0.95(tJ= 7.4Hz 3H). MASS: ESI [M +H] . 344.13; Elemental anal. calcd. for C16H17N504 C, 55.97; H, 4.99; N, 20.40; 0,18.64; found C, 55.87; H, 5.03; N, 20.43; 0, 18.67.<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 139756-02-8, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 139756-02-8, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[157,131],"tags":[126],"class_list":["post-819","post","type-post","status-publish","format-standard","hentry","category-139756-02-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSome scientific research about 139756-02-8<\/title>\n<meta name=\"description\" content=\"A common compound: 139756-02-8, name is 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. 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