{"id":8164,"date":"2021-12-16T03:41:24","date_gmt":"2021-12-15T19:41:24","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=8164"},"modified":"2021-12-16T03:41:24","modified_gmt":"2021-12-15T19:41:24","slug":"an-update-on-the-compound-challenge-3-methyl-1-p-tolyl-5-pyrazolone-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=8164","title":{"rendered":"An update on the compound challenge: 3-Methyl-1-p-tolyl-5-pyrazolone"},"content":{"rendered":"<p>I found the field of Chemistry very interesting. Saw the article One-Pot Asymmetric Synthesis of Spiropyrazolone-Linked Cyclopropanes and Benzofurans through a General Michael Addition\/Chlorination\/Nucleophilic Substitution Sequence published in 2019. <a href=\"https:\/\/www.ambeed.com\/products\/86-92-0.html\">HPLC of Formula: C11H12N2O<\/a>, Reprint Addresses Xu, PF (corresponding author), Lanzhou Univ, Sch Chem &#038; Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.. The CAS is 86-92-0. Through research, I have a further understanding and discovery of 3-Methyl-1-p-tolyl-5-pyrazolone<\/p>\n<p>A sequential and general strategy has been successfully developed for the synthesis of spiropyrazolone scaffolds. This intriguing transformation of the asymmetric multicomponent catalysis process was realized with the combination of Michael addition\/chlorination\/nucleophilic substitution in a one-pot sequence, giving rise to a series of spiropyrazolones with fully substituted cyclopropanes and spiro-dihydrobenzofurans containing continuous stereogenic centers in good yields with excellent stereoselectivities.<\/p>\n<p><a href=\"https:\/\/www.ambeed.com\/products\/86-92-0.html\">HPLC of Formula: C11H12N2O<\/a>. Welcome to talk about 86-92-0, If you have any questions, you can contact Lu, H; Zhang, HX; Tan, CY; Liu, JY; Wei, H; Xu, PF or send Email.<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.tet.2019.130916\">Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/86-92-0.html\">HPLC of Formula: C11H12N2O<\/a>. Welcome to talk about 86-92-0, If you have any questions, you can contact Lu, H; Zhang, HX; Tan, CY; Liu, JY; Wei, H; Xu, PF or send Email.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[675,131],"tags":[717],"class_list":["post-8164","post","type-post","status-publish","format-standard","hentry","category-86-92-0","category-pyrazoles-derivatives","tag-m-w150-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>An update on the compound challenge: 3-Methyl-1-p-tolyl-5-pyrazolone | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"I found the field of Chemistry very interesting. Saw the article One-Pot Asymmetric Synthesis of Spiropyrazolone-Linked Cyclopropanes and Benzofurans through a General Michael Addition\/Chlorination\/Nucleophilic Substitution Sequence published in 2019. HPLC of Formula: C11H12N2O, Reprint Addresses Xu, PF (corresponding author), Lanzhou Univ, Sch Chem &amp; Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.. The CAS is 86-92-0. Through research, I have a further understanding and discovery of 3-Methyl-1-p-tolyl-5-pyrazolone\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=8164\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"An update on the compound challenge: 3-Methyl-1-p-tolyl-5-pyrazolone | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"I found the field of Chemistry very interesting. Saw the article One-Pot Asymmetric Synthesis of Spiropyrazolone-Linked Cyclopropanes and Benzofurans through a General Michael Addition\/Chlorination\/Nucleophilic Substitution Sequence published in 2019. HPLC of Formula: C11H12N2O, Reprint Addresses Xu, PF (corresponding author), Lanzhou Univ, Sch Chem &amp; Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.. The CAS is 86-92-0. 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Saw the article One-Pot Asymmetric Synthesis of Spiropyrazolone-Linked Cyclopropanes and Benzofurans through a General Michael Addition\/Chlorination\/Nucleophilic Substitution Sequence published in 2019. HPLC of Formula: C11H12N2O, Reprint Addresses Xu, PF (corresponding author), Lanzhou Univ, Sch Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.. The CAS is 86-92-0. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"An update on the compound challenge: 3-Methyl-1-p-tolyl-5-pyrazolone | pyrazoles-derivatives","description":"I found the field of Chemistry very interesting. Saw the article One-Pot Asymmetric Synthesis of Spiropyrazolone-Linked Cyclopropanes and Benzofurans through a General Michael Addition\/Chlorination\/Nucleophilic Substitution Sequence published in 2019. HPLC of Formula: C11H12N2O, Reprint Addresses Xu, PF (corresponding author), Lanzhou Univ, Sch Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.. The CAS is 86-92-0. Through research, I have a further understanding and discovery of 3-Methyl-1-p-tolyl-5-pyrazolone","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=8164","og_locale":"en_US","og_type":"article","og_title":"An update on the compound challenge: 3-Methyl-1-p-tolyl-5-pyrazolone | pyrazoles-derivatives","og_description":"I found the field of Chemistry very interesting. Saw the article One-Pot Asymmetric Synthesis of Spiropyrazolone-Linked Cyclopropanes and Benzofurans through a General Michael Addition\/Chlorination\/Nucleophilic Substitution Sequence published in 2019. HPLC of Formula: C11H12N2O, Reprint Addresses Xu, PF (corresponding author), Lanzhou Univ, Sch Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.. The CAS is 86-92-0. Through research, I have a further understanding and discovery of 3-Methyl-1-p-tolyl-5-pyrazolone","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=8164","og_site_name":"pyrazoles-derivatives","article_published_time":"2021-12-15T19:41:24+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=8164","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=8164","name":"An update on the compound challenge: 3-Methyl-1-p-tolyl-5-pyrazolone | pyrazoles-derivatives","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2021-12-15T19:41:24+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"I found the field of Chemistry very interesting. Saw the article One-Pot Asymmetric Synthesis of Spiropyrazolone-Linked Cyclopropanes and Benzofurans through a General Michael Addition\/Chlorination\/Nucleophilic Substitution Sequence published in 2019. HPLC of Formula: C11H12N2O, Reprint Addresses Xu, PF (corresponding author), Lanzhou Univ, Sch Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.. The CAS is 86-92-0. Through research, I have a further understanding and discovery of 3-Methyl-1-p-tolyl-5-pyrazolone","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=8164#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=8164"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=8164#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"An update on the compound challenge: 3-Methyl-1-p-tolyl-5-pyrazolone"}]},{"@type":"WebSite","@id":"https:\/\/www.pyrazoles-derivatives.com\/#website","url":"https:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1","name":"Jessica.F","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/","url":"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g","contentUrl":"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g","caption":"Jessica.F"}}]}},"_links":{"self":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts\/8164","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=8164"}],"version-history":[{"count":0,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts\/8164\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=8164"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=8164"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=8164"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}