{"id":815,"date":"2020-10-19T11:29:01","date_gmt":"2020-10-19T03:29:01","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=815"},"modified":"2020-10-19T11:29:01","modified_gmt":"2020-10-19T03:29:01","slug":"brief-introduction-of-1-phenyl-1h-pyrazole-4-carboxylic-acid","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=815","title":{"rendered":"Brief introduction of 1-Phenyl-1H-pyrazole-4-carboxylic acid"},"content":{"rendered":"

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1134-50-5 name is 1-Phenyl-1H-pyrazole-4-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 1134-50-5<\/a><\/p>\n

[00240j To a solution of 1-phenyl-1H-pyrazole-4-carboxylic acid (590 mg, 3.1 mmol) in THF (6.9 mL) at rt was added borane-THF complex (6.2 mL, 6.2 mmol, 1 M in THF), and the reaction mixture was stirred over night. The mixture was quenched by the slowaddition of 1M NaOH and pouring into water. The mixture was extracted with ether (2x). The combined organics were washed with water and brine, dried over Na2SO4, andconcentrated to give Example 22A a white solid. MS (ESI) m\/z 175.1 (M+H). The crude product was used in the next synthetic step without further purification.<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Phenyl-1H-pyrazole-4-carboxylic acid, and friends who are interested can also refer to it.<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Phenyl-1H-pyrazole-4-carboxylic acid, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[155,131],"tags":[126],"class_list":["post-815","post","type-post","status-publish","format-standard","hentry","category-1134-50-5","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nBrief introduction of 1-Phenyl-1H-pyrazole-4-carboxylic acid<\/title>\n<meta name=\"description\" content=\"As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1134-50-5 name is 1-Phenyl-1H-pyrazole-4-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 1134-50-5\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=815\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Brief introduction of 1-Phenyl-1H-pyrazole-4-carboxylic acid\" \/>\n<meta property=\"og:description\" content=\"As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1134-50-5 name is 1-Phenyl-1H-pyrazole-4-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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