{"id":810,"date":"2020-10-16T11:08:38","date_gmt":"2020-10-16T03:08:38","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=810"},"modified":"2020-10-16T11:08:38","modified_gmt":"2020-10-16T03:08:38","slug":"share-a-compound-1-methyl-1h-pyrazole-4-carbaldehyde","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=810","title":{"rendered":"Share a compound : 1-Methyl-1H-pyrazole-4-carbaldehyde"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25016-11-9, name is 1-Methyl-1H-pyrazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., 25016-11-9<\/a><\/p>\n

103a) (E)-tert-Butyl 3-(1 -methyl-1 H-pyrazol-4-yl)acrylate To a solution of tert-butyl 2-(diethoxyphosphoryl)acetate (12.60 g, 49.9 mmol) in tetrahydrofuran (THF) (30 mL) was added NaH 60% dispersion in mineral oil (2.179 g, 54.5 mmol) slowly. The mixture was stirred for 10 min at room temperature. A solution of 1 -methyl-1 H-pyrazole-4-carbaldehyde (5.0 g, 45.4 mmol) in tetrahydrofuran (THF) (30 mL) was added slowly. After addition, the reaction mixture was stirred for 20 min at room temperature. The LCMS showed a complete reaction. The mixture was diluted with water and extracted with ethyl acetate. The organic extract was washed with water and dried over anhydrous MgSCv It was filtered and the filtrate was concentrated to give the crude product which was then purified on the Combiflash column chromatography eluting with a gradient of 0 to 50% ethyl acetate in hexanes. The title compound was obtained as clear colorless oil (9.0 g, 43.2 mmol, 95 % yield). LC-MS m\/z 208.9 (M+H)+, 0.93 min (ret. time).<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[151,131],"tags":[126],"class_list":["post-810","post","type-post","status-publish","format-standard","hentry","category-25016-11-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nShare a compound : 1-Methyl-1H-pyrazole-4-carbaldehyde<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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