{"id":805,"date":"2020-10-16T11:08:38","date_gmt":"2020-10-16T03:08:38","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=805"},"modified":"2020-10-16T11:08:38","modified_gmt":"2020-10-16T03:08:38","slug":"a-new-synthetic-route-of-1h-pyrazol-4-ylmethanol","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=805","title":{"rendered":"A new synthetic route of (1H-Pyrazol-4-yl)methanol"},"content":{"rendered":"

25222-43-9<\/a>, A common compound: 25222-43-9, name is (1H-Pyrazol-4-yl)methanol, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.<\/p>\n

A mixture of (5S,7S)-2-bromo-7-fluoro-5-phenyl-6,7-dihydro-5H-pyrrolo[l,2-b] [l,2,4]triazole (300 mg, 1.06 mmol), copper(l) iodide (1064 mg, 10.63 mmol), (lSSj-N lS -dimethylcyclohexane-l- diamine (1210 mg, 8.51 mmol), cesium carbonate (1039 mg, 3.19 mmol) and (lH-pyrazol-4- yl)methanol (1064 mg, 10.63 mmol) in 1,4-dioxane (2.5 mL) was heated at 140 \u00a1\u00e3C for 3h a sealed tube under microwave. After cooled, the mixture was diluted with water (30 mL) and extracted with ethyl acetate (3 x 15 mL). The combined organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, 100-200 mesh, 0 to 15percent MeOH in isopropyl acetate) to afford final product (169 mg, 53percent) as a white solid. LC-MS T = 0.92 min, m\/z = 300.1 (M+H) +. LCMS (5 to 95percent acetonitrile in water + 0.1percent formic acid over 2 mins) retention time 0.92 min, ESI+ found [M+H] = 300.1<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (1H-Pyrazol-4-yl)methanol, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (1H-Pyrazol-4-yl)methanol, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[146,131],"tags":[145],"class_list":["post-805","post","type-post","status-publish","format-standard","hentry","category-25222-43-9","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nA new synthetic route of (1H-Pyrazol-4-yl)methanol<\/title>\n<meta name=\"description\" content=\"25222-43-9, A common compound: 25222-43-9, name is (1H-Pyrazol-4-yl)methanol, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=805\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new synthetic route of (1H-Pyrazol-4-yl)methanol\" \/>\n<meta property=\"og:description\" content=\"25222-43-9, A common compound: 25222-43-9, name is (1H-Pyrazol-4-yl)methanol, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"http:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/cn.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/cn.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A new synthetic route of (1H-Pyrazol-4-yl)methanol","description":"25222-43-9, A common compound: 25222-43-9, name is (1H-Pyrazol-4-yl)methanol, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. 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