{"id":802,"date":"2020-10-16T11:08:38","date_gmt":"2020-10-16T03:08:38","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=802"},"modified":"2020-10-16T11:08:38","modified_gmt":"2020-10-16T03:08:38","slug":"sources-of-common-compounds-82560-12-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=802","title":{"rendered":"Sources of common compounds: 82560-12-1"},"content":{"rendered":"

82560-12-1<\/a>, Name is 3-Amino-5-tert-butylpyrazole, 82560-12-1, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.<\/p>\n

3-(tert-butyl)-lH-pyrazole-5-amine (1.00 g, 7.18 mmol), 3-bromo-5- hydroxypyridine (1.14 g, 6.53 mmol), copper (I) iodide (62.0 mg, 0.33 mmol), K2CO3 (1.90 g, 13.7 mmol) and trans-N, N’-dimethylcyclohexane- l ,2-diamine (186 mg, 1.31 mmol), were weighed in a 20 mL microwave vial fitted with a stirrer bar and sealed with a crimped septum. The vial was then evacuated and purged with N2, and anhydrous toluene (10 mL) added. The resulting mixture vacuum degassed and purged with N2, and then heated at 100C for 24 h. The resulting dark suspension was diluted with EtOAc and filtered through Celite, washed with EtOAc and the filtrates concentrated in vacuo. The resulting residue was purified by FCC, eluting with 0-8% MeOH\/DCM, to afford the title compound (1.15 g, 76%). LCMS (Method 3): t 2.31 min, m\/z 233.2 [MH+]. NMR (300 MHz, CDC13): 1.32 (9H, s), 3.49 (1H, s), 5.55 (1H, s), 7.37 (1H, t, J = 2.3 Hz), 8.04 (1H, d, J = 2.5 Hz), 8.27 (1H, d, J = 2.1 Hz).<\/p>\n

Statistics shows that 3-Amino-5-tert-butylpyrazole is playing an increasingly important role. we look forward to future research findings about 82560-12-1.<\/p>\n","protected":false},"excerpt":{"rendered":"

Statistics shows that 3-Amino-5-tert-butylpyrazole is playing an increasingly important role. we look forward to future research findings about 82560-12-1.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[142,131],"tags":[126],"class_list":["post-802","post","type-post","status-publish","format-standard","hentry","category-82560-12-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSources of common compounds: 82560-12-1<\/title>\n<meta name=\"description\" content=\"82560-12-1, Name is 3-Amino-5-tert-butylpyrazole, 82560-12-1, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. 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The chemical synthesis route is as follows.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=802","og_locale":"en_US","og_type":"article","og_title":"Sources of common compounds: 82560-12-1","og_description":"82560-12-1, Name is 3-Amino-5-tert-butylpyrazole, 82560-12-1, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. 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