{"id":7959,"date":"2021-12-02T02:51:44","date_gmt":"2021-12-01T18:51:44","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=7959"},"modified":"2021-12-02T02:51:44","modified_gmt":"2021-12-01T18:51:44","slug":"the-shocking-revelation-of-1159408-65-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=7959","title":{"rendered":"The Shocking Revelation of  1159408-65-7"},"content":{"rendered":"<p>Today I&#8217;d like to introduce a new chemical compound, CAS is 1159408-65-7, <a href=\"https:\/\/www.ambeed.com\/products\/1159408-65-7.html\">COA of Formula: 1159408-65-7<\/a>, Name is 4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]-, 2,2,2-trifluoroacetate, Formula is C81H129F3N10O38, Molecular Weight is 1907.93g\/mol. Because of its complex structure and huge molecular weight, this compound is rarely understood. Now let me introduce some knowledge about its synthesis.<\/p>\n<p>The general reactant of this compound is 1-(Phenylmethyl) dodecanedioate\uff1b4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]-, 2,2,2-trifluoroacetate (1:1), Reagents is \uff1bDimethylformamideDiisopropylethylamine\uff1b1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxide, Catalyst(), Solvent is , Products , Synthetic Methods procedure :1. Add HBTU ( 3.28 g, 8.64 mmol ) and DIEA ( 4.10 mL, 23.58 mmol ) to a solution of dodecanoic acid monobenzyl ester ( 2.51 g, 7.86 mmol ) in DMF ( 80 mL ) and stir the resulting mixture for few minutes., 2. Add a solution of reactant ( 15 g, 5.24 mmol ) in DMF ( 20 mL ) and continue stirring at room temperature overnight., 3. Remove the solvents and volatiles under reduced pressure., 4. Dissolve the residue in DCM ( 200 mL ) , wash with saturated NaHCO3\u00a0( 100 mL ) and water ( 100 mL ) ., 5. Dry over anhydrous Na2SO4, evaporate the solvent under reduced pressure., Transfornation (Acylation of Nitrogen Nucleophiles by Carboxylic Acids. Characterization Data include &#8216;s Proton NMR Spectrum : ( 400 MHz, DMSO-d\u00a06\u00a0) : \u03b4 7.86\u20137.77 ( m, 6H,\u00a0NH\u00a0) ; 7.72 ( t,\u00a0J\u00a0= 5.7 Hz, 3H,\u00a0NH\u00a0) ; 7.39-7.28 ( m, 5H ) ; 6.97 ( s, 1H,\u00a0NH\u00a0) ; 5.20 ( d,\u00a0J\u00a0= 3.4 Hz, 3H,\u00a0sugar\u00a0H4\u00a0) ; 5.07 ( s, 2H ) ; 4.95 ( dd,\u00a0J\u00a0= 3.4, 11.2 Hz, 3H,\u00a0sugar H3\u00a0) ; 4.47 ( d,\u00a0J\u00a0= 8.5 Hz, 3H,\u00a0sugar H1\u00a0) ; 4.07\u20133.96 ( m, 9H,\u00a0sugar\u00a0H5, H6, H6\u2032\u00a0) ; 3.86 ( dt,\u00a0J\u00a0= 8.9, 11.2 Hz, 3H,\u00a0sugar H\u00a02\u00a0) ; 3.69 ( dt,\u00a0J\u00a0= 5.9, 9.9 Hz, 3H ) ; 3.60-3.45 ( m, 12H ) ; 3.39 ( dt,\u00a0J\u00a0= 6.3, 9.9 Hz, 3H ) ; 3.08-2.95 ( m, 12H ) ; 2.32 ( t,\u00a0J\u00a0= 7.4 Hz, 2H ) ; 2.26 ( t,\u00a0J\u00a0= 6.3 Hz, 6H ) ; 2.09 ( s, 9H ) , 2.03 ( t,\u00a0J\u00a0= 7.0 Hz, 8H ) ; 1.98 ( s, 9H ) ; 1.88 ( s, 9H ) , 1.76 ( s, 9H ) ; 1.56\u20131.36 ( m, 22H ) ; 1.28\u20131.14 ( m, 12H ) ., Carbon-13 NMR : ( 126 MHz, DMSO-d\u00a06\u00a0) : \u03b4 172.8, 172.5, 171.9, 170.1, 170.0, 169.9, 169.6, 169.4, 136.3, 128.4, 128.0, 127.9, 101.0, 70.5, 69.8, 68.7, 68.3, 67.3, 66.7, 65.3, 61.4, 59.5, 49.4, 36.4, 36.3, 36.0, 35.9, 35.1, 33.5, 29.5, 28.9, 28.9, 28.8, 28.7, 28.6, 28.6, 28.4, 25.3, 24.5, 22.8, 21.9, 20.5, 20.5, 20.4., Mass Spectrum: MS calc. for C98H154N10O39: 2095.03; found: 2118.05 ( M+Na+, MALDI-TOF, matrix: HABA ) ., State is offwhite solid<\/p>\n<p>I&#8217;m so glad you had the patience to read the whole article, if you want know more about 1159408-65-7, <a href=\"https:\/\/www.ambeed.com\/products\/1159408-65-7.html\">COA of Formula: 1159408-65-7<\/a>, you can browse my other blog.<\/p>\n<p>Reference:<br \/><a href=https:\/\/pubs.acs.org\/doi\/10.1021\/ja505986a>CAS Method Number\u00a03-353-CAS-9716164<\/a>,<br \/>,<a href=https:\/\/pubs.acs.org\/doi\/10.1021\/ja505986a>CAS Method Number\u00a03-367-CAS-11845945<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>I&#8217;m so glad you had the patience to read the whole article, if you want know more about 1159408-65-7, <a href=\"https:\/\/www.ambeed.com\/products\/1159408-65-7.html\">COA of Formula: 1159408-65-7<\/a>, you can browse my other blog.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[718,131],"tags":[719],"class_list":["post-7959","post","type-post","status-publish","format-standard","hentry","category-1159408-65-7","category-pyrazoles-derivatives","tag-m-w1000-2000"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The Shocking Revelation of 1159408-65-7 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Today I&#039;d like to introduce a new chemical compound, CAS is 1159408-65-7, COA of Formula: 1159408-65-7, Name is 4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]-, 2,2,2-trifluoroacetate, Formula is C81H129F3N10O38, Molecular Weight is 1907.93g\/mol. Because of its complex structure and huge molecular weight, this compound is rarely understood. Now let me introduce some knowledge about its synthesis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=7959\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Shocking Revelation of 1159408-65-7 | pyrazoles-derivatives\" \/>\n<meta property=\"og:description\" content=\"Today I&#039;d like to introduce a new chemical compound, CAS is 1159408-65-7, COA of Formula: 1159408-65-7, Name is 4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]-, 2,2,2-trifluoroacetate, Formula is C81H129F3N10O38, Molecular Weight is 1907.93g\/mol. Because of its complex structure and huge molecular weight, this compound is rarely understood. Now let me introduce some knowledge about its synthesis.\" \/>\n<meta property=\"og:url\" content=\"http:\/\/www.pyrazoles-derivatives.com\/?p=7959\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-12-01T18:51:44+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=7959\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=7959\",\"name\":\"The Shocking Revelation of 1159408-65-7 | pyrazoles-derivatives\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-12-01T18:51:44+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Today I'd like to introduce a new chemical compound, CAS is 1159408-65-7, COA of Formula: 1159408-65-7, Name is 4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]-, 2,2,2-trifluoroacetate, Formula is C81H129F3N10O38, Molecular Weight is 1907.93g\/mol. Because of its complex structure and huge molecular weight, this compound is rarely understood. Now let me introduce some knowledge about its synthesis.\",\"breadcrumb\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=7959#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/www.pyrazoles-derivatives.com\/?p=7959\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=7959#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"The Shocking Revelation of 1159408-65-7\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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Because of its complex structure and huge molecular weight, this compound is rarely understood. Now let me introduce some knowledge about its synthesis.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"http:\/\/www.pyrazoles-derivatives.com\/?p=7959","og_locale":"en_US","og_type":"article","og_title":"The Shocking Revelation of 1159408-65-7 | pyrazoles-derivatives","og_description":"Today I'd like to introduce a new chemical compound, CAS is 1159408-65-7, COA of Formula: 1159408-65-7, Name is 4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]-, 2,2,2-trifluoroacetate, Formula is C81H129F3N10O38, Molecular Weight is 1907.93g\/mol. Because of its complex structure and huge molecular weight, this compound is rarely understood. Now let me introduce some knowledge about its synthesis.","og_url":"http:\/\/www.pyrazoles-derivatives.com\/?p=7959","og_site_name":"pyrazoles-derivatives","article_published_time":"2021-12-01T18:51:44+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"http:\/\/www.pyrazoles-derivatives.com\/?p=7959","url":"http:\/\/www.pyrazoles-derivatives.com\/?p=7959","name":"The Shocking Revelation of 1159408-65-7 | pyrazoles-derivatives","isPartOf":{"@id":"http:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2021-12-01T18:51:44+00:00","author":{"@id":"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Today I'd like to introduce a new chemical compound, CAS is 1159408-65-7, COA of Formula: 1159408-65-7, Name is 4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]-, 2,2,2-trifluoroacetate, Formula is C81H129F3N10O38, Molecular Weight is 1907.93g\/mol. Because of its complex structure and huge molecular weight, this compound is rarely understood. Now let me introduce some knowledge about its synthesis.","breadcrumb":{"@id":"http:\/\/www.pyrazoles-derivatives.com\/?p=7959#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["http:\/\/www.pyrazoles-derivatives.com\/?p=7959"]}]},{"@type":"BreadcrumbList","@id":"http:\/\/www.pyrazoles-derivatives.com\/?p=7959#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"http:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"The Shocking Revelation of 1159408-65-7"}]},{"@type":"WebSite","@id":"http:\/\/www.pyrazoles-derivatives.com\/#website","url":"http:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"http:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1","name":"Jessica.F","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/","url":"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g","contentUrl":"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g","caption":"Jessica.F"}}]}},"_links":{"self":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts\/7959","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=7959"}],"version-history":[{"count":0,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=\/wp\/v2\/posts\/7959\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=7959"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=7959"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pyrazoles-derivatives.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=7959"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}