{"id":7925,"date":"2021-11-30T05:18:04","date_gmt":"2021-11-29T21:18:04","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=7925"},"modified":"2021-11-30T05:18:04","modified_gmt":"2021-11-29T21:18:04","slug":"never-underestimate-the-influence-of-1159408-65-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=7925","title":{"rendered":"Never Underestimate The Influence Of 1159408-65-7"},"content":{"rendered":"

Today I’d like to introduce a new chemical compound, CAS is 1159408-65-7, Computed Properties of 1159408-65-7<\/a>, Name is 4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]-, 2,2,2-trifluoroacetate, Formula is C81H129F3N10O38, Molecular Weight is 1907.93g\/mol. Because of its complex structure and huge molecular weight, this compound is rarely understood. Now let me introduce some knowledge about its synthesis.<\/p>\n

The general reactant of this compound is 5-[[3,4,6-Tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]pentanoic acid\uff1bPhenylmethyl\u00a0N-[2-[3-[(3-aminopropyl)amino]-3-oxopropoxy]-1,1-bis[[3-[(3-aminopropyl)amino]-3-oxopropoxy]methyl]ethyl]carbamate, Reagents is 1-Hydroxybenzotriazole,Diisopropylethylamine,1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxide, Catalyst(), Solvent is Dimethylformamide, Products Phenylmethyl 8,14-dioxo-3,3-bis[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-18-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]-5-oxa-2,9,13-triazaoctadecanoate, Yield:\u00a058%, Synthetic Methods procedure :1. Add HOBt ( 25.00 g, 0.16 mmol ) and HBTU ( 75.15 g, 198.15 mmol ) to a solution of triamine ( 35.0 g, 54 mmol ) and the acid ( 80.54 g, 180.10 mmol ) in DMF ( 300 mL ) ., 2. Add DIEA ( 94 mL, 544 mmol ) slowly to above mixture., 3. Stir the reaction for 3 hours at room temperature, dilute with water and extract the mixture with ether ( 300 mL ) ., 4. Separate the water phase, extract with DCM ( 2 x 500 mL ) and wash the combined organic layers consecutively with saturated NaHCO3\u00a0( 400 mL ) , water ( 2 x 300 mL ) and brine ( 300 mL ) ., 5. Dry over anhydrous Na2SO4, evaporate the solvent under reduced pressure., Transfornation (Acylation of Nitrogen Nucleophiles by Carboxylic Acids. Characterization Data include ‘s Proton NMR Spectrum : ( 400 MHz, DMSO-d\u00a06\u00a0) : \u03b4 7.87\u20137.76 ( m, 6H,\u00a0NH\u00a0) ; 7.71 ( t,\u00a0J\u00a0= 5.7 Hz, 3H,\u00a0NH\u00a0) ; 7.37-7.25 ( m, 5H ) ; 6.52 ( brs, 1H,\u00a0NH\u00a0) ; 5.20 ( d,\u00a0J\u00a0= 3.4 Hz, 3H,\u00a0sugar\u00a0H4\u00a0) ; 5.00\u20134.92 ( m, 5H ) ; 4.47 ( d,\u00a0J\u00a0= 8.5 Hz, 3H,\u00a0sugar H1\u00a0) ; 4.06\u20133.97 ( m, 9H,\u00a0sugar\u00a0H5, H6, H6\u2032\u00a0) ; 3.86 ( dt,\u00a0J\u00a0= 8.8, 11.1 Hz, 3H,\u00a0sugar H2\u00a0) ; 3.69 ( dt,\u00a0J\u00a0= 5.6, 9.9 Hz, 3H ) ; 3.53 ( t,\u00a0J\u00a0= 6.4 Hz, 6H ) ; 3.47 ( s broad, 6H ) ; 3.39 ( dt,\u00a0J\u00a0= 6.4, 9.9 Hz, 3H ) ; 3.07-2.97 ( m, 12H ) ; 2.26 ( t,\u00a0J\u00a0= 6.4 Hz, 6H ) ; 2.09 ( s, 9H ) ; 2.03 ( t,\u00a0J\u00a0= 7.0 Hz, 6H ) ; 1.98 ( s, 9H ) ; 1.88 ( s, 9H ) ; 1.76 ( s, 9H ) ; 1.58\u20131.35 ( m, 18H ) ., Carbon-13 NMR : ( 126 MHz, DMSO-d\u00a06\u00a0) : \u03b4171.9, 170.0, 169.9, 169.9, 169.6, 169.4, 137.2, 128.3, 127.7, 127.5, 101.0, 79.2, 70.5, 69.8, 68.7, 68.2, 67.3, 66.7, 61.4, 58.8, 49.4, 36.4, 36.3, 36.1, 35.0, 29.3, 28.6, 22.8, 21.8, 20.5, 20.5, 20.4., HRMS: Mass calc. for C87H134N10O38: 1926.88; found: 1949.89 [M+Na+, MALDI-TOF, matrix: 2- ( 4-hydroxyphenylazo ) benzoic acid ( HABA ) ]., State is pale yellow solid<\/p>\n

I’m so glad you had the patience to read the whole article, if you want know more about 1159408-65-7, Computed Properties of 1159408-65-7<\/a>, you can browse my other blog.<\/p>\n

Reference:
CAS Method Number\u00a03-353-CAS-9716164<\/a>,
,CAS Method Number\u00a03-367-CAS-11845945<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

I’m so glad you had the patience to read the whole article, if you want know more about 1159408-65-7, Computed Properties of 1159408-65-7<\/a>, you can browse my other blog.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[718,131],"tags":[719],"class_list":["post-7925","post","type-post","status-publish","format-standard","hentry","category-1159408-65-7","category-pyrazoles-derivatives","tag-m-w1000-2000"],"yoast_head":"\nNever Underestimate The Influence Of 1159408-65-7 | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"Today I'd like to introduce a new chemical compound, CAS is 1159408-65-7, Computed Properties of 1159408-65-7, Name is 4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-\u03b2-D-galactopyranosyl]oxy]-, 2,2,2-trifluoroacetate, Formula is C81H129F3N10O38, Molecular Weight is 1907.93g\/mol. 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