{"id":7117,"date":"2021-10-25T03:13:09","date_gmt":"2021-10-24T19:13:09","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=7117"},"modified":"2021-10-25T03:13:09","modified_gmt":"2021-10-24T19:13:09","slug":"an-update-on-the-compound-challenge-3-methyl-1-p-tolyl-5-pyrazolone-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=7117","title":{"rendered":"An update on the compound challenge: 3-Methyl-1-p-tolyl-5-pyrazolone"},"content":{"rendered":"

In 2019 ANGEW CHEM INT EDIT published article about ASYMMETRIC-SYNTHESIS; SPIROPYRAZOLONES; ISOXAZOLINONES; DENDRALENES; ANNULATION; GENERATION; REACTIVITY; YLIDES in [Li, Long; Luo, Pengfei; Deng, Yuhua; Shao, Zhihui] Yunnan Univ, Key Lab Med Chem Nat Resource, State Key Lab Conservat & Utilizat Bioresources Y, Minist Educ,Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China in 2019, Cited 65. The Name is 3-Methyl-1-p-tolyl-5-pyrazolone. Through research, I have a further understanding and discovery of 86-92-0. Computed Properties of C11H12N2O<\/a><\/p>\n

The first Pd-catalyzed asymmetric allenylic [4+1] cycloaddition was successfully developed. Alternatively, tuning the Pd catalyst switched the reactivity toward an unprecedented [4+3] cycloaddition\/cross-coupling. Ligands play a vital role in controlling the reaction pathway, allowing highly selective access to different products from identical substrates. Biological evaluation of the obtained compounds led to the discovery of new antitumor targets. A possible mechanism is proposed, suggesting two interesting catalytic cycles for the cycloaddition with palladium-butadienyls. This study also demonstrated the potential and utility of allenic esters as 1,4-biselectrophiles and C-4 synthons for participating in cycloaddition reactions.<\/p>\n

Computed Properties of C11H12N2O<\/a>. About 3-Methyl-1-p-tolyl-5-pyrazolone, If you have any questions, you can contact Li, L; Luo, PF; Deng, YH; Shao, ZH or concate me.<\/p>\n

Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

Computed Properties of C11H12N2O<\/a>. About 3-Methyl-1-p-tolyl-5-pyrazolone, If you have any questions, you can contact Li, L; Luo, PF; Deng, YH; Shao, ZH or concate me.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[675,131],"tags":[717],"class_list":["post-7117","post","type-post","status-publish","format-standard","hentry","category-86-92-0","category-pyrazoles-derivatives","tag-m-w150-200"],"yoast_head":"\nAn update on the compound challenge: 3-Methyl-1-p-tolyl-5-pyrazolone | pyrazoles-derivatives<\/title>\n<meta name=\"description\" content=\"In 2019 ANGEW CHEM INT EDIT published article about ASYMMETRIC-SYNTHESIS; SPIROPYRAZOLONES; ISOXAZOLINONES; DENDRALENES; ANNULATION; GENERATION; REACTIVITY; YLIDES in [Li, Long; Luo, Pengfei; Deng, Yuhua; Shao, Zhihui] Yunnan Univ, Key Lab Med Chem Nat Resource, State Key Lab Conservat & Utilizat Bioresources Y, Minist Educ,Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China in 2019, Cited 65. 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